Telsan
Generic Name
Telmisartan
Manufacturer
Navana Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| telsan 40 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Telsan 40 mg Tablet contains Telmisartan, an Angiotensin II Receptor Blocker (ARB), used to treat high blood pressure (hypertension) and reduce the risk of cardiovascular events such as heart attack or stroke.
Uses & Indications
Dosage
Adults
The usual recommended dose is 40 mg once daily. The dose may be increased to a maximum of 80 mg once daily if necessary to achieve blood pressure control.
Elderly
No dosage adjustment is generally required for elderly patients. Close monitoring is advised.
Renal_impairment
No dosage adjustment is required for patients with mild to moderate renal impairment. For severe renal impairment or hemodialysis, initial dose should be 20 mg once daily.
How to Take
Telsan 40 mg tablet should be taken orally once daily with or without food. It is recommended to take it at approximately the same time each day.
Mechanism of Action
Telmisartan selectively blocks the binding of angiotensin II to the AT1 receptor in various tissues, leading to vasodilation, reduced aldosterone secretion, and overall reduction in blood pressure. It does not inhibit ACE.
Pharmacokinetics
Onset
Within 3 hours for antihypertensive effect.
Excretion
Primarily excreted unchanged via bile into feces (over 97%). Minimal renal excretion.
Half life
Approximately 24 hours, allowing for once-daily dosing.
Absorption
Rapidly but variably absorbed from the gastrointestinal tract. Absolute bioavailability is approximately 42-58%. Food slightly reduces absorption.
Metabolism
Almost exclusively metabolized by conjugation to form the pharmacologically inactive acylglucuronide. Not metabolized by cytochrome P450 system.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients.
- Second and third trimesters of pregnancy.
- Biliary obstructive disorders.
- Severe hepatic impairment.
- Concomitant use of aliskiren in patients with diabetes mellitus or renal impairment (GFR < 60 mL/min/1.73 m²).
Drug Interactions
Digoxin
Increased plasma concentrations of digoxin. Monitor digoxin levels.
Lithium
Increased serum lithium concentrations and toxicity. Monitor lithium levels.
Aliskiren
Contraindicated in patients with diabetes or renal impairment.
NSAIDs (e.g., ibuprofen, naproxen)
Reduced antihypertensive effect and increased risk of worsening renal function.
Diuretics (e.g., furosemide, hydrochlorothiazide)
Increased risk of hypotension and renal impairment.
Potassium-sparing diuretics (e.g., spironolactone) or potassium supplements
Increased risk of hyperkalemia.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Limited data are available on overdose. The most likely manifestations would be hypotension and tachycardia; bradycardia could also occur. Treatment is symptomatic and supportive. Telmisartan is not removed by hemodialysis.
Pregnancy & Lactation
Telsan is contraindicated during the second and third trimesters of pregnancy due to risks of fetal injury and death. It is not recommended during the first trimester. Discontinue as soon as pregnancy is detected. Telmisartan is also contraindicated during lactation due to potential adverse effects on the nursing infant.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients.
- Second and third trimesters of pregnancy.
- Biliary obstructive disorders.
- Severe hepatic impairment.
- Concomitant use of aliskiren in patients with diabetes mellitus or renal impairment (GFR < 60 mL/min/1.73 m²).
Drug Interactions
Digoxin
Increased plasma concentrations of digoxin. Monitor digoxin levels.
Lithium
Increased serum lithium concentrations and toxicity. Monitor lithium levels.
Aliskiren
Contraindicated in patients with diabetes or renal impairment.
NSAIDs (e.g., ibuprofen, naproxen)
Reduced antihypertensive effect and increased risk of worsening renal function.
Diuretics (e.g., furosemide, hydrochlorothiazide)
Increased risk of hypotension and renal impairment.
Potassium-sparing diuretics (e.g., spironolactone) or potassium supplements
Increased risk of hyperkalemia.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Limited data are available on overdose. The most likely manifestations would be hypotension and tachycardia; bradycardia could also occur. Treatment is symptomatic and supportive. Telmisartan is not removed by hemodialysis.
Pregnancy & Lactation
Telsan is contraindicated during the second and third trimesters of pregnancy due to risks of fetal injury and death. It is not recommended during the first trimester. Discontinue as soon as pregnancy is detected. Telmisartan is also contraindicated during lactation due to potential adverse effects on the nursing infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Patent expired
WHO Essential Medicine
YesClinical Trials
Telmisartan has undergone extensive clinical trials demonstrating its efficacy and safety in managing hypertension and reducing cardiovascular risk, particularly in patients with Type 2 Diabetes Mellitus or established atherosclerotic cardiovascular disease.
Lab Monitoring
- Blood pressure monitoring regularly.
- Renal function (serum creatinine, blood urea nitrogen, GFR) before and periodically during treatment.
- Serum potassium levels, especially in patients with renal impairment or those taking potassium-sparing diuretics.
Doctor Notes
- Always assess patient's renal function and serum potassium levels before initiating Telmisartan and monitor periodically.
- Counsel patients on the importance of adherence to therapy and lifestyle modifications.
- Avoid concomitant use with aliskiren in diabetic patients or those with renal impairment.
- Discontinue immediately if pregnancy is detected due to severe fetal harm.
Patient Guidelines
- Take Telsan exactly as prescribed by your doctor, preferably at the same time each day.
- Do not stop taking the medication abruptly without consulting your doctor, even if you feel well.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Report any unusual or severe side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
Telsan may cause dizziness or drowsiness, especially at the start of treatment or when the dose is increased. If you experience these symptoms, avoid driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Adopt a healthy lifestyle including a balanced, low-sodium diet rich in fruits and vegetables.
- Engage in regular physical activity as advised by your doctor.
- Maintain a healthy body weight and limit alcohol consumption.
- Quit smoking if you are a smoker, as it can worsen hypertension.
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