Telukast
Generic Name
Montelukast
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| telukast 10 mg tablet | ৳ 17.50 | ৳ 175.00 |
| telukast 4 mg chewable tablet | ৳ 7.00 | ৳ 70.00 |
| telukast 5 mg chewable tablet | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Telukast is a brand of Montelukast, a leukotriene receptor antagonist used for the prevention and long-term treatment of asthma and for the relief of symptoms of seasonal and perennial allergic rhinitis.
Uses & Indications
Dosage
Adults
10 mg orally once daily, in the evening.
Elderly
No dosage adjustment necessary.
Renal_impairment
No dosage adjustment necessary.
How to Take
Take orally once daily in the evening, with or without food. For asthma, take in the evening. For allergic rhinitis, time of administration may be individualized. For exercise-induced bronchoconstriction, take at least 2 hours before exercise.
Mechanism of Action
Montelukast selectively blocks the cysteinyl leukotriene 1 (CysLT1) receptor, preventing the binding of leukotrienes (LTC4, LTD4, LTE4). These leukotrienes are potent inflammatory mediators involved in asthma and allergic rhinitis, causing bronchoconstriction, mucus secretion, vascular permeability, and eosinophil recruitment.
Pharmacokinetics
Onset
Within 1 day (for asthma/rhinitis symptoms improvement)
Excretion
Primarily excreted in feces via bile (approximately 86%), very little in urine.
Half life
2.7 to 5.5 hours
Absorption
Rapidly absorbed after oral administration. Peak plasma concentration reached in 2-4 hours.
Metabolism
Extensively metabolized in the liver by CYP2C8, CYP3A4, and CYP2C9.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients.
Drug Interactions
Gemfibrozil
May increase Montelukast plasma concentration.
Phenobarbital
May decrease Montelukast plasma concentration.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefit outweighs the potential risk. Excreted in breast milk, caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Available in pharmacies nationwide in Bangladesh
Approval Status
Approved by FDA (for Montelukast) and DGDA (for Telukast brand)
Patent Status
Patent expired (for generic Montelukast)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials support its efficacy and safety in asthma and allergic rhinitis across various age groups.
Lab Monitoring
- No routine lab monitoring required. Liver function tests may be considered in patients with pre-existing hepatic impairment or if symptoms of hepatic dysfunction develop.
Doctor Notes
- Emphasize that Montelukast is for prophylaxis and chronic treatment, not for acute attacks.
- Counsel patients on potential neuropsychiatric side effects.
- Advise patients not to discontinue abruptly.
Patient Guidelines
- Do not use to treat acute asthma attacks.
- Continue taking even if symptoms improve.
- Report any mood changes or behavioral disturbances to your doctor.
- Do not stop other asthma medications unless advised by your doctor.
Missed Dose Advice
If a dose is missed, take the next dose at the usual time. Do not double the dose to make up for a missed dose.
Driving Precautions
May cause dizziness or drowsiness. Patients should be advised to exercise caution when driving or operating machinery.
Lifestyle Advice
- Avoid known allergens.
- Maintain a clean home environment.
- Avoid triggers like smoke and strong odors.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.