Tempanil
Generic Name
Paracetamol 500 mg
Manufacturer
HealthCare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tempanil 500 mg tablet | ৳ 1.20 | N/A |
Description
Overview of the medicine
Tempanil 500 mg Tablet is a medication containing Paracetamol, primarily used for relieving mild to moderate pain and reducing fever. It works by blocking chemical messengers in the brain that tell us we have pain and are hot.
Uses & Indications
Dosage
Adults
Oral: 500 mg to 1000 mg (1-2 tablets) every 4 to 6 hours as needed. Do not exceed 4000 mg (8 tablets) in 24 hours.
Elderly
Similar to adult dosage; however, caution should be exercised in patients with impaired renal or hepatic function.
Renal_impairment
Dosage interval may need to be extended in severe renal impairment (e.g., 500 mg every 6-8 hours for CrCl < 10 mL/min).
How to Take
Tempanil 500 mg Tablet should be taken orally with water. It can be taken with or without food. Do not chew or crush the tablet.
Mechanism of Action
Paracetamol is thought to act primarily in the central nervous system (CNS) by inhibiting prostaglandin synthesis, which reduces pain and fever. It has weak peripheral anti-inflammatory activity.
Pharmacokinetics
Onset
Pain relief: 30-60 minutes; Fever reduction: within 60 minutes.
Excretion
Excreted primarily in the urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
Plasma elimination half-life is typically 1 to 4 hours, primarily 2-3 hours.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 30 to 60 minutes after oral administration.
Metabolism
Extensively metabolized in the liver mainly by conjugation with glucuronic acid and sulfate. A small portion is metabolized by cytochrome P450 enzymes to a toxic intermediate, N-acetyl-p-benzoquinone imine (NAPQI), which is rapidly detoxified by conjugation with glutathione.
Side Effects
Contraindications
- Hypersensitivity to Paracetamol or any other component of the formulation.
- Severe hepatic impairment or active liver disease.
Drug Interactions
Alcohol
Increased risk of hepatotoxicity when consumed chronically and excessively with paracetamol.
Cholestyramine
May decrease the absorption of paracetamol if taken within one hour.
Metoclopramide and Domperidone
May increase the absorption rate of paracetamol.
Warfarin and other coumarin anticoagulants
Increased anticoagulant effect, leading to increased bleeding risk, particularly with prolonged use of high doses of paracetamol.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose of paracetamol can cause severe, potentially fatal, liver damage. Symptoms may include nausea, vomiting, abdominal pain, sweating, and loss of appetite, often appearing 24-48 hours after ingestion. Management involves gastric decontamination and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Paracetamol is generally considered safe for use during all stages of pregnancy when used at recommended doses for the shortest possible duration. It is also considered safe for use during breastfeeding, as only small amounts pass into breast milk and are unlikely to cause harm to the infant. Always consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to Paracetamol or any other component of the formulation.
- Severe hepatic impairment or active liver disease.
Drug Interactions
Alcohol
Increased risk of hepatotoxicity when consumed chronically and excessively with paracetamol.
Cholestyramine
May decrease the absorption of paracetamol if taken within one hour.
Metoclopramide and Domperidone
May increase the absorption rate of paracetamol.
Warfarin and other coumarin anticoagulants
Increased anticoagulant effect, leading to increased bleeding risk, particularly with prolonged use of high doses of paracetamol.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose of paracetamol can cause severe, potentially fatal, liver damage. Symptoms may include nausea, vomiting, abdominal pain, sweating, and loss of appetite, often appearing 24-48 hours after ingestion. Management involves gastric decontamination and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Paracetamol is generally considered safe for use during all stages of pregnancy when used at recommended doses for the shortest possible duration. It is also considered safe for use during breastfeeding, as only small amounts pass into breast milk and are unlikely to cause harm to the infant. Always consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 3 to 5 years from the date of manufacture, consult the packaging for exact expiry.
Availability
Pharmacies, Supermarkets
Approval Status
Approved (Widely available OTC)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Paracetamol is a well-established drug with extensive clinical data. Ongoing post-marketing surveillance and studies continue to monitor its safety and efficacy.
Lab Monitoring
- Liver function tests (especially in cases of overdose, prolonged use, or pre-existing liver conditions)
- Renal function tests (in patients with pre-existing renal impairment or during overdose)
Doctor Notes
- Educate patients on the maximum daily dose and the risk of liver damage with overdose.
- Advise patients to check labels of other OTC medications to avoid accidental paracetamol overdose.
- Counsel on alcohol interaction and increased hepatotoxicity risk.
Patient Guidelines
- Do not exceed the recommended dose; taking more than the maximum daily dose can cause serious liver damage.
- Avoid taking other medications containing paracetamol simultaneously.
- Consult a doctor if pain or fever persists for more than a few days, or if new symptoms appear.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Tempanil 500 mg Tablet is generally not expected to affect the ability to drive or operate machinery. However, if you experience dizziness or drowsiness (which are rare side effects), you should avoid such activities.
Lifestyle Advice
- Maintain adequate hydration, especially when suffering from fever.
- Avoid or limit alcohol consumption while taking paracetamol to reduce the risk of liver damage.
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Global Brand Names
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