Tenaxit
Generic Name
Tenaxol Hydrochloride
Manufacturer
Meditopix Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tenaxit 05 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Tenaxit 0.5 mg Tablet is a beta-adrenergic blocker primarily used to treat essential hypertension, angina pectoris, and certain anxiety disorders. It works by blocking the action of certain natural chemicals in your body, like epinephrine, on the heart and blood vessels.
Uses & Indications
Dosage
Adults
Initially 0.5 mg once daily, adjusted based on response up to a maximum of 2 mg daily.
Elderly
Lower initial dose (e.g., 0.25 mg) and gradual titration recommended due to increased sensitivity and potential for renal impairment.
Renal_impairment
Dose adjustment may be necessary in severe renal impairment; use with caution.
How to Take
Take orally, with or without food, at the same time each day.
Mechanism of Action
Tenaxol hydrochloride selectively blocks beta-1 adrenergic receptors, reducing heart rate, myocardial contractility, and cardiac output. It also inhibits the release of renin, leading to a decrease in angiotensin II and aldosterone, further contributing to its antihypertensive effect.
Pharmacokinetics
Onset
Within 1-2 hours
Excretion
Mainly renal, with a small portion excreted in feces.
Half life
Approximately 3-4 hours
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability approximately 50-60%.
Metabolism
Primarily hepatic, extensive first-pass metabolism.
Side Effects
Contraindications
- •Sinus bradycardia
- •Second or third-degree atrioventricular block
- •Cardiogenic shock
- •Decompensated heart failure
- •Severe bronchial asthma
Drug Interactions
NSAIDs
May reduce the antihypertensive effect of Tenaxit.
Clonidine
Risk of rebound hypertension upon clonidine withdrawal; withdraw Tenaxit several days before clonidine.
Digitalis Glycosides
Increased risk of bradycardia.
Calcium Channel Blockers (e.g., Verapamil, Diltiazem)
Increased risk of bradycardia and hypotension; monitor cardiac function closely.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe bradycardia, hypotension, heart failure, and bronchospasm. Management involves symptomatic and supportive treatment, including atropine for bradycardia, vasopressors for hypotension, and bronchodilators for bronchospasm.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit outweighs the potential risk to the fetus. It is excreted in breast milk; caution should be exercised when Tenaxit is administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies nationwide in Bangladesh
Approval Status
Approved by DGDA
Patent Status
No active patent
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Global Brand Names
International brand names for this medicine
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