Tenobis-A
Generic Name
Teneligliptin 25 mg and Amlodipine 5 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tenobis a 25 mg tablet | ৳ 6.00 | ৳ 84.00 |
Description
Overview of the medicine
Tenobis-A 25 mg tablet is a combination medication containing Teneligliptin, an antidiabetic, and Amlodipine, an antihypertensive. It is used to treat patients with type 2 diabetes mellitus and hypertension when treatment with both active ingredients is appropriate.
Uses & Indications
Dosage
Adults
One tablet once daily. Dosage may be individualized based on the patient's current glycemic control, blood pressure, and tolerance to the individual components.
Elderly
No specific dose adjustment is generally required, but caution should be exercised due to potential age-related decline in renal and hepatic function.
Renal_impairment
For Teneligliptin, no dose adjustment is needed for mild to moderate renal impairment; for severe impairment, close monitoring. For Amlodipine, no dose adjustment is required for renal impairment. Consult a physician.
How to Take
Take orally, once daily, with or without food, at approximately the same time each day.
Mechanism of Action
Teneligliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that prevents the breakdown of incretins, leading to increased insulin secretion and reduced glucagon levels, thus lowering blood glucose. Amlodipine is a dihydropyridine calcium channel blocker that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle, causing peripheral vasodilation and reduction in blood pressure.
Pharmacokinetics
Onset
Teneligliptin: Blood glucose lowering effects within hours. Amlodipine: Antihypertensive effects typically begin within 6-9 hours.
Excretion
Teneligliptin: Primarily via urine and feces. Amlodipine: Excreted mainly in the urine as inactive metabolites, with less than 10% as unchanged drug.
Half life
Teneligliptin: Approximately 24 hours (effective half-life). Amlodipine: 30-50 hours.
Absorption
Teneligliptin is rapidly absorbed with good bioavailability. Amlodipine is slowly but almost completely absorbed from the GI tract (bioavailability 64-90%).
Metabolism
Teneligliptin: Primarily metabolized by CYP3A4 and FMO3. Amlodipine: Extensively metabolized in the liver to inactive metabolites via CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Teneligliptin, Amlodipine, or any component of the formulation.
- Diabetic ketoacidosis.
- Acute pancreatitis or history of pancreatitis (for Teneligliptin).
- Cardiogenic shock, unstable angina, severe aortic stenosis (for Amlodipine).
Drug Interactions
Digoxin
Teneligliptin may cause a minor increase in Digoxin levels.
CYP3A4 Inducers (e.g., Rifampicin)
May decrease Amlodipine plasma concentrations.
CYP3A4 Inhibitors (e.g., Ketoconazole, Diltiazem)
May increase Amlodipine plasma concentrations, requiring dose adjustment.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose of Teneligliptin may cause mild hypoglycemia. Amlodipine overdose can lead to excessive peripheral vasodilation with marked hypotension, reflex tachycardia, and possibly shock. Management includes symptomatic and supportive measures, including monitoring of blood glucose and blood pressure, and for Amlodipine, IV fluids and vasopressors may be needed.
Pregnancy & Lactation
Not recommended during pregnancy or lactation unless the potential benefit outweighs the potential risk to the fetus or infant. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Teneligliptin, Amlodipine, or any component of the formulation.
- Diabetic ketoacidosis.
- Acute pancreatitis or history of pancreatitis (for Teneligliptin).
- Cardiogenic shock, unstable angina, severe aortic stenosis (for Amlodipine).
Drug Interactions
Digoxin
Teneligliptin may cause a minor increase in Digoxin levels.
CYP3A4 Inducers (e.g., Rifampicin)
May decrease Amlodipine plasma concentrations.
CYP3A4 Inhibitors (e.g., Ketoconazole, Diltiazem)
May increase Amlodipine plasma concentrations, requiring dose adjustment.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose of Teneligliptin may cause mild hypoglycemia. Amlodipine overdose can lead to excessive peripheral vasodilation with marked hypotension, reflex tachycardia, and possibly shock. Management includes symptomatic and supportive measures, including monitoring of blood glucose and blood pressure, and for Amlodipine, IV fluids and vasopressors may be needed.
Pregnancy & Lactation
Not recommended during pregnancy or lactation unless the potential benefit outweighs the potential risk to the fetus or infant. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved in Bangladesh
Patent Status
Generic versions available
Clinical Trials
Both Teneligliptin and Amlodipine have undergone extensive clinical trials demonstrating their efficacy and safety individually and in various combinations for diabetes and hypertension management.
Lab Monitoring
- Fasting and postprandial blood glucose levels
- HbA1c levels (periodically)
- Blood pressure monitoring
- Renal function (e.g., serum creatinine, eGFR)
- Liver function tests (baseline and periodically)
Doctor Notes
- Ensure patient is suitable for combination therapy; consider titrating individual components first if necessary.
- Monitor blood pressure and glycemic control regularly (HbA1c).
- Counsel patients on lifestyle modifications, including diet, exercise, and adherence to medication.
Patient Guidelines
- Take the medication regularly as prescribed by your doctor, even if you feel well.
- Do not stop taking the tablet abruptly without consulting your doctor.
- Report any unusual or severe side effects to your healthcare provider immediately.
- Follow recommended dietary and exercise plans to help manage your diabetes and hypertension.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medicine may cause dizziness or fatigue. If you experience these symptoms, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain a healthy and balanced diet low in saturated fats and refined sugars.
- Engage in regular physical activity.
- Monitor blood glucose and blood pressure regularly at home.
- Quit smoking and limit alcohol intake.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.