Tenoxim
Generic Name
Piroxicam
Manufacturer
Example Pharmaceutical Co. Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tenoxim 20 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Tenoxim 20 mg Tablet contains Piroxicam, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and stiffness caused by arthritis and other inflammatory conditions. It works by blocking the body's production of certain natural substances that cause inflammation.
Uses & Indications
Dosage
Adults
Typically 20 mg once daily, or 10 mg twice daily, for inflammatory conditions. For acute musculoskeletal disorders, 40 mg once daily for the first two days, then 20 mg once daily for 7 to 14 days.
Elderly
Use with caution; lower doses may be considered due to increased risk of adverse effects. Generally, the lowest effective dose for the shortest duration.
Renal_impairment
Reduced dosage may be necessary; monitor renal function closely. Not recommended for severe renal impairment.
How to Take
Take orally, preferably with or after food to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water.
Mechanism of Action
Piroxicam is a non-selective NSAID that inhibits the activity of cyclooxygenase (COX-1 and COX-2) enzymes. This inhibition reduces the synthesis of prostaglandins, which are mediators of inflammation, pain, and fever.
Pharmacokinetics
Onset
Analgesic effect usually starts within 1 hour, anti-inflammatory effects may take several days to weeks.
Excretion
Excreted predominantly in the urine (approximately 60%) and feces (approximately 40%) as metabolites.
Half life
Approximately 30-86 hours (average 50 hours), allowing for once-daily dosing.
Absorption
Well absorbed from the gastrointestinal tract, reaching peak plasma concentrations typically within 3-5 hours after oral administration.
Metabolism
Extensively metabolized in the liver, primarily via hydroxylation, followed by conjugation with glucuronic acid.
Side Effects
Contraindications
- •Hypersensitivity to Piroxicam or other NSAIDs (e.g., aspirin)
- •History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- •Active gastrointestinal bleeding, ulceration, or perforation
- •Severe heart failure
- •Severe renal or hepatic impairment
- •Last trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased plasma methotrexate levels, leading to toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration and bleeding.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects, increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Antiplatelet agents (e.g., Aspirin, Clopidogrel)
Increased risk of gastrointestinal bleeding.
ACE inhibitors/Angiotensin Receptor Blockers (ARBs)
Reduced antihypertensive effect, increased risk of renal impairment.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, lethargy, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered if recent ingestion. Monitor renal function and acid-base balance.
Pregnancy & Lactation
Not recommended during pregnancy, especially in the third trimester, due to potential risks to the fetus (e.g., premature closure of the ductus arteriosus). Use with caution during lactation; Piroxicam is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Available in pharmacies worldwide
Approval Status
Approved by relevant health authorities (e.g., FDA, DGDA)
Patent Status
Generic available (off-patent)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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