Tensa
Generic Name
Clonazepam
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tensa 05 mg tablet | ৳ 3.50 | N/A |
Description
Overview of the medicine
Clonazepam is a benzodiazepine used to treat various seizure disorders and panic disorder. It has anxiolytic, anticonvulsant, muscle relaxant, and sedative properties.
Uses & Indications
Dosage
Adults
Initial: 0.25 mg orally twice daily for panic disorder; 0.5 mg orally three times daily for seizure disorders. May be increased gradually. Max: 4 mg/day for panic, 20 mg/day for seizures.
Elderly
Lower initial doses (e.g., 0.25 mg daily for panic disorder) and slower titration due to increased sensitivity.
Renal_impairment
No specific dosage adjustment recommended, but use with caution.
How to Take
Take orally with or without food. Swallow whole, do not crush or chew.
Mechanism of Action
Enhances the effect of gamma-aminobutyric acid (GABA) at the GABA-A receptor, leading to increased chloride influx and neuronal hyperpolarization, thus reducing neuronal excitability.
Pharmacokinetics
Onset
20-60 minutes (oral)
Excretion
Excreted primarily in the urine as metabolites, with a small amount in feces.
Half life
18-50 hours
Absorption
Rapidly and completely absorbed from the GI tract. Peak plasma concentrations reached within 1-4 hours.
Metabolism
Primarily metabolized in the liver via nitroreduction to 7-aminoclonazepam and glucuronidation.
Side Effects
Contraindications
- Acute narrow-angle glaucoma
- Significant liver disease
- Hypersensitivity to benzodiazepines or any component of the formulation
Drug Interactions
Flumazenil
Can reverse the effects of clonazepam.
Carbamazepine
May increase clonazepam clearance.
CNS depressants (opioids, alcohol, other benzodiazepines)
Increased sedative effects, respiratory depression.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include drowsiness, confusion, impaired coordination, diminished reflexes, and coma. Management is supportive, including airway management, gastric lavage, and activated charcoal if appropriate. Flumazenil may be considered in severe cases, but with caution due to risk of seizures in benzodiazepine-dependent patients.
Pregnancy & Lactation
Pregnancy Category D. Use only if potential benefit outweighs risk. Excreted in breast milk, not recommended during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of clonazepam for its approved indications.
Lab Monitoring
- Liver function tests (baseline and periodically for prolonged use)
- Complete blood count (periodically for prolonged use)
Doctor Notes
- Emphasize gradual tapering to avoid withdrawal.
- Counsel patients on the risks of concomitant opioid/alcohol use.
- Monitor for signs of depression or suicidal ideation.
Patient Guidelines
- Do not stop taking this medicine abruptly due to withdrawal symptoms.
- Avoid driving or operating heavy machinery until you know how this medicine affects you.
- Report any unusual mood changes or thoughts of self-harm to your doctor immediately.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not double dose.
Driving Precautions
May cause drowsiness, dizziness, and impaired concentration. Patients should be warned not to drive or operate hazardous machinery until they are reasonably certain that clonazepam does not adversely affect their ability to engage in such activities.
Lifestyle Advice
- Maintain a regular sleep schedule.
- Avoid caffeine and alcohol, especially during treatment.
- Engage in stress-reducing activities like yoga or meditation.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.