terbicon
Generic Name
terbinafine
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| terbicon 1 cream | ৳ 80.00 | N/A |
Description
Overview of the medicine
Terbinafine 1% cream is an antifungal medication used to treat various fungal skin infections such as athlete's foot, jock itch, and ringworm. It works by killing the fungi causing the infection.
Uses & Indications
Dosage
Adults
Apply thinly to the affected area and surrounding skin once or twice daily. Treatment duration is typically 1 week for tinea pedis, tinea cruris, tinea corporis, and cutaneous candidiasis, and 2 weeks for pityriasis versicolor. Continue for a few days after symptoms resolve.
Elderly
No special dosage adjustments needed for elderly patients.
Renal_impairment
No dosage adjustments needed for topical use in patients with renal impairment.
How to Take
Clean and dry the affected skin area thoroughly before applying the cream. Apply a thin layer of cream to the affected skin and the immediate surrounding area, and rub it in gently. Wash hands immediately after application.
Mechanism of Action
Terbinafine inhibits squalene epoxidase, an enzyme in the fungal ergosterol biosynthesis pathway. This leads to an accumulation of squalene within the fungal cell membrane and a deficiency of ergosterol, resulting in fungal cell death.
Pharmacokinetics
Onset
Symptomatic improvement usually begins within a few days; full mycological cure may take 1-4 weeks depending on the infection.
Excretion
Mainly through kidneys and feces for systemically absorbed drug, but systemic excretion is minimal for topical application.
Half life
Local skin concentrations persist for several weeks after cessation of treatment. Systemic half-life after oral administration is 200-400 hours, but not clinically relevant for topical use.
Absorption
Less than 5% systemic absorption after topical application; detectable in the stratum corneum within hours.
Metabolism
Minimal metabolism at the site of application; hepatic metabolism is significant for orally administered terbinafine, but negligible for topical.
Side Effects
Contraindications
- Hypersensitivity to terbinafine or any of the excipients in the cream.
Drug Interactions
Topical
Systemic absorption is minimal, so drug interactions are highly unlikely with topical terbinafine.
Storage
Store below 30°C. Do not freeze. Protect from light and moisture. Keep out of reach of children.
Overdose
Topical overdose is unlikely to cause systemic effects due to minimal absorption. If excessive amount is applied, wash it off. In case of accidental ingestion, seek medical advice immediately.
Pregnancy & Lactation
Use during pregnancy and lactation only if clearly needed and under medical supervision, as human data are limited. Consult your doctor.
Side Effects
Contraindications
- Hypersensitivity to terbinafine or any of the excipients in the cream.
Drug Interactions
Topical
Systemic absorption is minimal, so drug interactions are highly unlikely with topical terbinafine.
Storage
Store below 30°C. Do not freeze. Protect from light and moisture. Keep out of reach of children.
Overdose
Topical overdose is unlikely to cause systemic effects due to minimal absorption. If excessive amount is applied, wash it off. In case of accidental ingestion, seek medical advice immediately.
Pregnancy & Lactation
Use during pregnancy and lactation only if clearly needed and under medical supervision, as human data are limited. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months (Specific to manufacturer and storage conditions)
Availability
Pharmacies, drugstores
Approval Status
Generally approved worldwide
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of topical terbinafine 1% cream for various dermatophyte infections and cutaneous candidiasis.
Lab Monitoring
- No specific lab monitoring is typically required for topical terbinafine use.
Doctor Notes
- Emphasize patient education on hygiene and adherence to the full treatment course.
- Advise patients to seek medical attention if symptoms worsen or do not improve after the recommended treatment period.
- Differentiate from other fungal treatments that may have different mechanisms or durations.
Patient Guidelines
- Wash your hands thoroughly before and after applying the cream.
- Avoid contact with eyes, nose, mouth, and other mucous membranes.
- Complete the full prescribed course of treatment even if symptoms improve to prevent recurrence.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one.
Driving Precautions
Topical terbinafine cream has no known effect on the ability to drive or operate machinery.
Lifestyle Advice
- Keep the affected area clean and dry.
- Wear loose-fitting, breathable clothing.
- Avoid sharing towels, clothing, or footwear to prevent spreading the infection.
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