Terbisol
Generic Name
Terbinafine
Manufacturer
General Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| terbisol 1 cream | ৳ 80.00 | N/A |
Description
Overview of the medicine
Terbisol (Terbinafine) is an allylamine antifungal used to treat fungal infections of the skin, hair, and nails. It works by preventing the growth of fungus.
Uses & Indications
Dosage
Adults
For onychomycosis, 250 mg once daily for 6 weeks (fingernails) or 12 weeks (toenails). For tinea corporis/cruris, 250 mg once daily for 2-4 weeks. For tinea pedis, 250 mg once daily for 2-6 weeks.
Elderly
No specific dose adjustment needed unless severe renal or hepatic impairment.
Renal_impairment
Reduce dose by 50% if creatinine clearance <50 mL/min.
How to Take
Oral tablets can be taken with or without food. Topical forms should be applied to the affected area once or twice daily.
Mechanism of Action
Terbinafine inhibits squalene epoxidase, an enzyme in the fungal ergosterol biosynthesis pathway. This leads to a deficiency in ergosterol and an intracellular accumulation of squalene, which is toxic to the fungal cell, leading to cell death.
Pharmacokinetics
Onset
Clinical improvement usually seen within weeks, complete cure may take months for nail infections.
Excretion
Primarily excreted in urine (70-80%) as metabolites, small amount in feces.
Half life
Terminal elimination half-life is about 200-400 hours (for tablet).
Absorption
Well absorbed orally, bioavailability around 40% due to first-pass metabolism. Peak plasma concentrations reached within 2 hours.
Metabolism
Extensively metabolized by CYP enzymes (primarily CYP2C9, CYP1A2, CYP3A4, CYP2C8, and CYP2D6) in the liver.
Side Effects
Contraindications
- Hypersensitivity to terbinafine
- Chronic or active liver disease
Drug Interactions
Caffeine
Terbinafine may reduce caffeine clearance.
Cimetidine
May decrease clearance of terbinafine.
Rifampicin
May increase clearance of terbinafine.
CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
May increase terbinafine plasma levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include headache, nausea, epigastric pain, and dizziness. Treatment is symptomatic and supportive, including gastric lavage if ingested recently.
Pregnancy & Lactation
Pregnancy category B. Use during pregnancy only if clearly needed. Excreted in breast milk, so avoid during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Available in pharmacies
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Extensive clinical trials have demonstrated efficacy and safety in various fungal infections.
Lab Monitoring
- Liver function tests (baseline and periodic)
- Complete blood count (if treatment >6 weeks or immunosuppressed patients)
Doctor Notes
- Advise patients on the importance of completing the full course.
- Monitor liver function tests, especially for patients with pre-existing liver conditions.
Patient Guidelines
- Complete the full course of treatment even if symptoms improve.
- Report any signs of liver problems (e.g., persistent nausea, dark urine, jaundice).
- Avoid alcohol during treatment.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances in some patients, so caution is advised when driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene, especially for feet.
- Wear breathable footwear and cotton socks.
- Avoid sharing towels or shoes.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.