Tetclin
Generic Name
Tetracycline Hydrochloride 250 mg Capsule
Manufacturer
Generic Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tetclin 250 mg capsule | ৳ 1.00 | ৳ 10.00 |
Description
Overview of the medicine
Tetclin 250 mg Capsule contains Tetracycline, a broad-spectrum antibiotic used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
General dosage: 250-500 mg every 6 hours. For acne: 250-500 mg daily in single or divided doses.
Elderly
No specific dose adjustment for elderly patients, but monitor renal function carefully.
Renal_impairment
Reduce dose in patients with impaired renal function (e.g., creatinine clearance < 80 mL/min); consult product labeling for specific guidelines.
How to Take
Take orally with a full glass of water, preferably 1 hour before or 2 hours after meals. Avoid taking with milk, dairy products, or antacids, as these can significantly reduce absorption.
Mechanism of Action
Tetracycline inhibits bacterial protein synthesis by reversibly binding to the 30S ribosomal subunit, thereby preventing the attachment of aminoacyl-tRNA to the ribosomal acceptor site.
Pharmacokinetics
Onset
Onset of action is typically within hours; peak plasma concentrations occur 2-4 hours after oral administration.
Excretion
Excreted mainly unchanged in urine (30-60%) and feces (via bile).
Half life
Approximately 6-11 hours.
Absorption
Incomplete and variable oral absorption (60-80%), significantly reduced by food, dairy products, and antacids.
Metabolism
Limited hepatic metabolism; primarily undergoes enterohepatic recirculation.
Side Effects
Contraindications
- Hypersensitivity to tetracyclines
- Pregnancy and lactation
- Children under 8 years of age due to risk of permanent tooth discoloration and inhibition of bone growth
- Severe renal impairment (unless dosage is appropriately adjusted)
Drug Interactions
Penicillins
Tetracyclines are bacteriostatic and may interfere with the bactericidal action of penicillins. Avoid concomitant use.
Methoxyflurane
Concurrent use may result in fatal renal toxicity.
Oral contraceptives
May reduce the effectiveness of oral contraceptives, leading to breakthrough bleeding or unintended pregnancy.
Anticoagulants (e.g., Warfarin)
Tetracycline may potentiate the effects of anticoagulants, requiring dosage adjustment.
Antacids, Iron preparations, Calcium, Magnesium, Bismuth subsalicylate
Significantly reduce tetracycline absorption. Administer at least 2 hours before or after tetracycline.
Storage
Store in a cool, dry place (below 30°C), away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, and diarrhea. Management is supportive, including gastric lavage or induced emesis, and symptomatic treatment. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category D. Contraindicated during pregnancy and lactation due to the risk of permanent tooth discoloration and inhibition of bone growth in the fetus/infant.
Side Effects
Contraindications
- Hypersensitivity to tetracyclines
- Pregnancy and lactation
- Children under 8 years of age due to risk of permanent tooth discoloration and inhibition of bone growth
- Severe renal impairment (unless dosage is appropriately adjusted)
Drug Interactions
Penicillins
Tetracyclines are bacteriostatic and may interfere with the bactericidal action of penicillins. Avoid concomitant use.
Methoxyflurane
Concurrent use may result in fatal renal toxicity.
Oral contraceptives
May reduce the effectiveness of oral contraceptives, leading to breakthrough bleeding or unintended pregnancy.
Anticoagulants (e.g., Warfarin)
Tetracycline may potentiate the effects of anticoagulants, requiring dosage adjustment.
Antacids, Iron preparations, Calcium, Magnesium, Bismuth subsalicylate
Significantly reduce tetracycline absorption. Administer at least 2 hours before or after tetracycline.
Storage
Store in a cool, dry place (below 30°C), away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, and diarrhea. Management is supportive, including gastric lavage or induced emesis, and symptomatic treatment. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category D. Contraindicated during pregnancy and lactation due to the risk of permanent tooth discoloration and inhibition of bone growth in the fetus/infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from the date of manufacture, depending on storage conditions.
Availability
Pharmacies, Hospitals
Approval Status
Approved (Widely approved globally)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Tetracycline has been extensively studied since its discovery, and its efficacy and safety profile are well-established through numerous clinical trials over decades.
Lab Monitoring
- Renal function tests (especially in long-term therapy or pre-existing renal impairment)
- Liver function tests (for prolonged high-dose therapy)
- Complete Blood Count (CBC) (occasionally for long-term therapy)
Doctor Notes
- Emphasize the importance of completing the full course of therapy to prevent antibiotic resistance.
- Advise patients about the significant interaction with dairy products, antacids, and iron supplements; recommend spacing dosages.
- Counsel on photosensitivity and the need for sun protection.
- Strictly contraindicated in pregnancy, lactation, and children under 8 years.
Patient Guidelines
- Take with plenty of water to prevent esophageal irritation.
- Avoid lying down for at least 30 minutes after taking the capsule.
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Avoid excessive sun exposure and use protective clothing/sunscreen due to photosensitivity.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double dose.
Driving Precautions
Tetracycline may cause dizziness or lightheadedness in some individuals. Patients should be cautioned about driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Avoid prolonged sun exposure and wear protective clothing outdoors.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.