Tetrabez
Generic Name
Doxycycline
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tetrabez 125 mg tablet | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Tetrabez 125 mg Tablet contains Doxycycline, a broad-spectrum tetracycline antibiotic used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
Typically 125 mg orally once daily, or as directed by physician. For severe infections, higher doses may be required (e.g., 200 mg on first day, then 100 mg daily).
Elderly
No specific dose adjustment typically required, but monitor renal function.
Renal_impairment
No dosage adjustment necessary, as it is primarily excreted non-renally.
How to Take
Take orally with a full glass of water, preferably in an upright position to prevent esophageal irritation. Can be taken with food to minimize gastrointestinal upset, but avoid dairy products, antacids, or iron supplements within 2-3 hours of dose.
Mechanism of Action
Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing the attachment of aminoacyl-tRNA to the ribosomal A site, thereby inhibiting bacterial growth.
Pharmacokinetics
Onset
Clinical effects typically seen within 1-2 hours.
Excretion
Mainly excreted in faeces as inactive chelates, with a smaller portion excreted in urine.
Half life
12-22 hours
Absorption
Well absorbed from the gastrointestinal tract, even in the presence of food or milk, though absorption may be slightly reduced by dairy products, antacids, or iron preparations.
Metabolism
Minimally metabolized; primarily inactivated by chelation in the gut.
Side Effects
Contraindications
- •Hypersensitivity to tetracyclines
- •Severe hepatic impairment
- •Pregnancy (especially second and third trimesters)
- •Lactation
- •Children under 8 years of age (due to potential for permanent tooth discoloration and bone growth inhibition)
Drug Interactions
Warfarin
May potentiate the anticoagulant effect.
Penicillins
May interfere with the bactericidal effect of penicillins.
Methotrexate
May increase methotrexate toxicity.
Oral contraceptives
May reduce the efficacy of oral contraceptives.
Antacids (aluminum, calcium, magnesium containing), Iron preparations, Bismuth subsalicylate
Can decrease the absorption of doxycycline.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Management involves gastric lavage, supportive care, and symptomatic treatment. Dialysis is not effective.
Pregnancy & Lactation
Category D in pregnancy (due to potential for tooth discoloration and bone growth inhibition in fetus). Avoid during lactation as it passes into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by Regulatory Authority
Patent Status
Patent Expired for Generic
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in
