Tevirax
Generic Name
Acyclovir
Manufacturer
Manufacturer name varies by region (e.g., Acme Pharma)
Country
Multiple countries
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tevirax 25 mg tablet | ৳ 90.00 | ৳ 900.00 |
Description
Overview of the medicine
Tevirax 25 mg Tablet contains Acyclovir, an antiviral drug used to treat infections caused by herpes viruses, including herpes simplex virus (cold sores, genital herpes) and varicella-zoster virus (chickenpox, shingles). Note that 25 mg is an unusually low strength for systemic adult use and specific product guidelines should be followed.
Uses & Indications
Dosage
Adults
Typical oral dosages vary from 200 mg to 800 mg, 2 to 5 times daily, depending on the indication. For 25 mg tablet, consult specific product information; generally, this strength is unusually low for systemic adult use and may be intended for specific, less common indications or patient groups.
Elderly
Dosage adjustments may be necessary based on renal function. Maintain adequate hydration.
Renal_impairment
Reduced dosage is required. For creatinine clearance <10 mL/min, dose frequency may be reduced (e.g., 200 mg every 12 hours for HSV).
How to Take
Tevirax tablets can be taken with or without food. It is important to drink plenty of water while taking this medicine to prevent kidney problems.
Mechanism of Action
Acyclovir is a synthetic guanosine analogue that is selectively taken up by herpesvirus-infected cells and converted to its active triphosphate form. Acyclovir triphosphate inhibits viral DNA synthesis by competing with deoxyguanosine triphosphate for viral DNA polymerase and by being incorporated into viral DNA, leading to chain termination.
Pharmacokinetics
Onset
Therapeutic effects may be observed within 24-48 hours of initiation.
Excretion
Mainly excreted unchanged in urine by glomerular filtration and tubular secretion.
Half life
Approximately 2.5 to 3 hours in adults with normal renal function.
Absorption
Poorly absorbed from the gastrointestinal tract; bioavailability is typically 10-30%.
Metabolism
Primarily metabolized in the liver to 9-carboxymethoxymethylguanine.
Side Effects
Contraindications
- Hypersensitivity to Acyclovir or Valacyclovir
Drug Interactions
Probenecid
Increases acyclovir plasma concentration and prolongs its half-life by reducing renal excretion.
Mycophenolate Mofetil
Increases plasma concentrations of both drugs.
Nephrotoxic drugs (e.g., NSAIDs, Cyclosporine, Aminoglycosides)
Increased risk of renal dysfunction when co-administered.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include increased serum creatinine and acute renal failure, agitation, confusion, hallucinations, and seizures. Treatment is symptomatic and supportive. Hemodialysis can significantly remove acyclovir from the blood.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but human studies are insufficient. Use during pregnancy only if clearly needed. Acyclovir is excreted into breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to Acyclovir or Valacyclovir
Drug Interactions
Probenecid
Increases acyclovir plasma concentration and prolongs its half-life by reducing renal excretion.
Mycophenolate Mofetil
Increases plasma concentrations of both drugs.
Nephrotoxic drugs (e.g., NSAIDs, Cyclosporine, Aminoglycosides)
Increased risk of renal dysfunction when co-administered.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include increased serum creatinine and acute renal failure, agitation, confusion, hallucinations, and seizures. Treatment is symptomatic and supportive. Hemodialysis can significantly remove acyclovir from the blood.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but human studies are insufficient. Use during pregnancy only if clearly needed. Acyclovir is excreted into breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture
Availability
Globally available in pharmacies and hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Generic available, patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established Acyclovir's efficacy and safety for various herpes virus infections since its approval in 1981.
Lab Monitoring
- Monitor renal function (serum creatinine, BUN) periodically, especially in patients with pre-existing renal impairment or those receiving concomitant nephrotoxic drugs.
- Monitor hydration status.
Doctor Notes
- Emphasize the importance of hydration to prevent renal toxicity.
- Counsel patients on adherence to the full treatment course to optimize outcomes and prevent resistance.
- Advise patients with genital herpes about transmission prevention measures.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Drink plenty of fluids while taking Acyclovir to help prevent kidney problems.
- Do not stop taking this medicine even if you feel better, as symptoms may recur.
- Avoid sexual contact if you have genital herpes to prevent transmission.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Acyclovir may cause dizziness or drowsiness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they are reasonably certain that the medicine does not adversely affect their ability to perform such activities.
Lifestyle Advice
- Maintain good hygiene to prevent spread of infection.
- Avoid touching active lesions to prevent self-inoculation or spread to others.
- Stay well-hydrated.
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International brand names for this medicine. Click a brand to search for detailed information.