Tgocef-DS
Generic Name
Cefixime
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tgocef ds 200 mg suspension | ৳ 320.00 | N/A |
Description
Overview of the medicine
Cefixime is a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections. It is effective against many Gram-positive and Gram-negative bacteria.
Uses & Indications
Dosage
Adults
Typically 400 mg once daily or 200 mg every 12 hours for 7-14 days, depending on the infection. This 200 mg DS suspension is primarily for pediatric use.
Elderly
Same as adults, but dose adjustment is recommended for severe renal impairment.
Renal_impairment
For creatinine clearance < 60 mL/min, dose adjustment is necessary. For CrCl 21-59 mL/min, 75% of the standard dose; for CrCl < 20 mL/min, 50% of the standard dose.
How to Take
Oral administration. The suspension should be reconstituted with water as directed and shaken well before each use. Can be taken with or without food. Complete the full course of medication even if symptoms improve.
Mechanism of Action
Cefixime works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the cross-linking of peptidoglycan chains essential for cell wall strength and rigidity, leading to cell lysis and death.
Pharmacokinetics
Onset
Peak plasma concentrations usually occur 2-6 hours after administration.
Excretion
Eliminated primarily by renal excretion (glomerular filtration and tubular secretion) with some biliary excretion.
Half life
Plasma half-life is typically 3-4 hours, potentially longer in elderly or renally impaired patients.
Absorption
Approximately 40-50% orally absorbed. Food can slightly delay absorption but does not significantly alter the extent of absorption.
Metabolism
Minimal hepatic metabolism; primarily excreted as unchanged drug.
Side Effects
Contraindications
- Known hypersensitivity to Cefixime, other cephalosporins, or penicillins.
- Patients with a history of severe allergic reactions to beta-lactam antibiotics.
Drug Interactions
Carbamazepine
Elevated carbamazepine levels have been reported when co-administered with cefixime.
Aminoglycosides
Potentially increased risk of nephrotoxicity (though less common with cefixime).
Warfarin and other anticoagulants
May increase prothrombin time (PT) with or without bleeding, requiring INR monitoring.
Storage
Store the dry powder below 30°C, protected from light and moisture. After reconstitution, store the suspension in a refrigerator (2-8°C) and discard any unused portion after the specified period (e.g., 7 or 14 days). Do not freeze.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Caution is advised when administered to a nursing mother as cefixime is excreted in small amounts in breast milk.
Side Effects
Contraindications
- Known hypersensitivity to Cefixime, other cephalosporins, or penicillins.
- Patients with a history of severe allergic reactions to beta-lactam antibiotics.
Drug Interactions
Carbamazepine
Elevated carbamazepine levels have been reported when co-administered with cefixime.
Aminoglycosides
Potentially increased risk of nephrotoxicity (though less common with cefixime).
Warfarin and other anticoagulants
May increase prothrombin time (PT) with or without bleeding, requiring INR monitoring.
Storage
Store the dry powder below 30°C, protected from light and moisture. After reconstitution, store the suspension in a refrigerator (2-8°C) and discard any unused portion after the specified period (e.g., 7 or 14 days). Do not freeze.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Caution is advised when administered to a nursing mother as cefixime is excreted in small amounts in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Dry powder: 24-36 months. Reconstituted suspension: 7-14 days when stored as directed (usually refrigerated).
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections across different age groups. Post-marketing surveillance continues to monitor its effects.
Lab Monitoring
- Periodic monitoring of renal function may be advisable during prolonged therapy, especially in patients with pre-existing renal impairment.
- Complete Blood Count (CBC) in patients on prolonged therapy.
Doctor Notes
- Assess patient's history for penicillin or cephalosporin hypersensitivity before prescribing.
- Monitor for signs of superinfection or C. difficile infection if diarrhea develops.
- Advise patients on the importance of completing the full course of antibiotics.
Patient Guidelines
- Take the medicine for the full prescribed duration, even if symptoms improve.
- Do not share your medication with others.
- Shake the suspension well before each use.
- Store the reconstituted suspension as directed, usually refrigerated.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Cefixime may cause dizziness or lightheadedness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain good hydration while on antibiotic therapy.
- Avoid self-medication for future infections.
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