Thiovit
Generic Name
Thioctic Acid 100 mg Tablet
Manufacturer
PharmaCo Inc.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| thiovit 100 mg tablet | ৳ 0.80 | N/A |
Description
Overview of the medicine
Thioctic acid is a naturally occurring compound that plays a vital role in metabolism. It is a powerful antioxidant, often used in the management of diabetic neuropathy.
Uses & Indications
Dosage
Adults
Typically 600 mg daily, but for Thiovit-100, 100 mg once or twice daily, or as directed by physician.
Elderly
No specific dose adjustment needed, but caution with comorbidities.
Renal_impairment
No specific dose adjustment for mild to moderate impairment. Use with caution in severe renal impairment.
How to Take
Oral. Can be taken with or without food, but some advise taking it 30 minutes before meals for better absorption.
Mechanism of Action
Thioctic acid acts as a coenzyme in mitochondrial dehydrogenase complexes, participating in energy metabolism. It also has potent antioxidant properties, scavenging free radicals and regenerating other antioxidants like Vitamin C and E.
Pharmacokinetics
Onset
Varies, but effects on neuropathic symptoms may take several weeks.
Excretion
Primarily through the kidneys as metabolites.
Half life
Approximately 20-50 minutes.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations usually within 30-60 minutes.
Metabolism
Extensive first-pass metabolism in the liver via beta-oxidation and S-methylation.
Side Effects
Contraindications
- Hypersensitivity to thioctic acid or any excipients
- Children and adolescents (due to lack of data)
Drug Interactions
Cisplatin
May reduce the effect of cisplatin.
Insulin and oral antidiabetic agents
May potentiate the hypoglycemic effect; blood glucose monitoring recommended.
Metal compounds (e.g., iron, magnesium, dairy products)
Thioctic acid forms chelates with metal ions, reducing absorption. Administer at different times.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, headache, and in severe cases, seizures or lactic acidosis. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use only if clearly needed and the potential benefits outweigh the risks. Consult a doctor. Limited data available.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Extensive clinical trials support its efficacy in diabetic polyneuropathy, showing improvements in neuropathic symptoms.
Lab Monitoring
- Blood glucose levels (for diabetic patients)
- Liver function tests (if liver conditions present)
Doctor Notes
- Inform patients about potential hypoglycemic effects, especially if on antidiabetic medication.
- Advise patients on proper administration to avoid interactions with metal ions.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking without consulting your doctor.
- Report any unusual side effects promptly.
Missed Dose Advice
Take the missed dose as soon as you remember. If it's almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
Thioctic acid is generally not expected to affect the ability to drive or operate machinery. However, if side effects like dizziness occur, avoid such activities.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Avoid excessive alcohol consumption.
- Manage underlying conditions like diabetes effectively.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.