Thyrox
Generic Name
Levothyroxine Sodium 75 mcg Tablet
Manufacturer
Abbott
Country
India
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| thyrox 75 mcg tablet | ৳ 3.10 | N/A |
Description
Overview of the medicine
Thyrox-75-mcg-tablet contains Levothyroxine Sodium, a synthetic thyroid hormone used to treat hypothyroidism and certain thyroid cancers.
Uses & Indications
Dosage
Adults
Initial dose 25-50 mcg daily, titrated by 12.5-25 mcg every 4-6 weeks based on TSH levels. Maintenance dose typically 50-200 mcg daily.
Elderly
Lower initial doses (e.g., 12.5-25 mcg daily) are recommended, with careful titration due to increased sensitivity.
Renal_impairment
No dosage adjustment usually required, but careful monitoring is advised.
How to Take
Take once daily on an empty stomach, at least 30-60 minutes before breakfast, or at bedtime (at least 3 hours after last meal) to optimize absorption.
Mechanism of Action
Levothyroxine acts as a replacement for natural thyroid hormones (T4). It binds to thyroid hormone receptors and exerts its metabolic effects by regulating gene expression.
Pharmacokinetics
Onset
Clinical effects are gradual, starting within 3-5 days, with full effects seen after several weeks of consistent dosing.
Excretion
Primarily excreted in the urine and feces (small amounts).
Half life
Approximately 6-7 days (euthyroid patients), shorter in hyperthyroid states, longer in hypothyroid states.
Absorption
Well absorbed from the gastrointestinal tract, primarily in the jejunum and ileum. Absorption is incomplete and variable, influenced by food and other medications.
Metabolism
Metabolized primarily in the liver by deiodination, forming active T3 and inactive metabolites.
Side Effects
Contraindications
- Untreated adrenal insufficiency
- Acute myocardial infarction
- Untreated thyrotoxicosis
- Hypersensitivity to levothyroxine or any excipients
Drug Interactions
Warfarin
Levothyroxine can enhance the anticoagulant effect of warfarin, requiring careful monitoring of INR.
Amiodarone
Can induce hypothyroidism or hyperthyroidism.
Oral contraceptives
May increase thyroid-binding globulin, requiring higher levothyroxine doses.
Proton pump inhibitors (PPIs)
May reduce gastric acidity, potentially impairing levothyroxine absorption.
Cholestyramine, colestipol, sucralfate
Can decrease levothyroxine absorption. Separate administration by at least 4-5 hours.
Antacids, iron supplements, calcium supplements
Can decrease levothyroxine absorption. Separate administration by at least 4 hours.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include signs of hyperthyroidism such as palpitations, tremor, anxiety, insomnia, sweating, weight loss. Treatment involves reducing the dose or temporarily discontinuing the drug, and symptomatic management.
Pregnancy & Lactation
Levothyroxine is considered safe and essential during pregnancy and lactation. Dosage requirements often increase during pregnancy. Regular TSH monitoring is crucial.
Side Effects
Contraindications
- Untreated adrenal insufficiency
- Acute myocardial infarction
- Untreated thyrotoxicosis
- Hypersensitivity to levothyroxine or any excipients
Drug Interactions
Warfarin
Levothyroxine can enhance the anticoagulant effect of warfarin, requiring careful monitoring of INR.
Amiodarone
Can induce hypothyroidism or hyperthyroidism.
Oral contraceptives
May increase thyroid-binding globulin, requiring higher levothyroxine doses.
Proton pump inhibitors (PPIs)
May reduce gastric acidity, potentially impairing levothyroxine absorption.
Cholestyramine, colestipol, sucralfate
Can decrease levothyroxine absorption. Separate administration by at least 4-5 hours.
Antacids, iron supplements, calcium supplements
Can decrease levothyroxine absorption. Separate administration by at least 4 hours.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include signs of hyperthyroidism such as palpitations, tremor, anxiety, insomnia, sweating, weight loss. Treatment involves reducing the dose or temporarily discontinuing the drug, and symptomatic management.
Pregnancy & Lactation
Levothyroxine is considered safe and essential during pregnancy and lactation. Dosage requirements often increase during pregnancy. Regular TSH monitoring is crucial.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of levothyroxine for thyroid hormone replacement therapy, dating back decades. Ongoing studies focus on optimal dosing strategies and long-term outcomes.
Lab Monitoring
- TSH (Thyroid-Stimulating Hormone) levels (primary monitoring parameter)
- Free T4 (Thyroxine) levels
- Clinical evaluation of symptoms
Doctor Notes
- Emphasize the importance of consistent daily dosing and taking on an empty stomach.
- Advise patients about potential drug/food interactions and spacing of medications.
- Educate on symptoms of over- and under-treatment and when to seek medical advice.
Patient Guidelines
- Take consistently at the same time each day.
- Do not switch brands without consulting your doctor.
- Inform your doctor about all other medications and supplements you are taking.
- Do not stop taking the medicine abruptly.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Levothyroxine is not known to impair the ability to drive or operate machinery. However, if you experience side effects like dizziness or tremor, exercise caution.
Lifestyle Advice
- Maintain a balanced diet.
- Engage in regular physical activity.
- Avoid smoking and excessive alcohol consumption.
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