Tiemis
Generic Name
Tiemis 5 mg Injection
Manufacturer
MediCorp Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tiemis 5 mg injection | ৳ 35.00 | N/A |
Description
Overview of the medicine
Tiemis 5 mg Injection is an antihistamine used to prevent and treat nausea, vomiting, and dizziness caused by motion sickness or other conditions. It works by blocking certain natural substances (histamine) that your body makes.
Uses & Indications
Dosage
Adults
5 mg IM/IV every 4-6 hours as needed, maximum 20 mg/day.
Elderly
Lower doses may be required, e.g., 2.5 mg IM/IV every 6-8 hours, considering increased sensitivity.
Renal_impairment
Use with caution; dose reduction may be necessary in severe renal dysfunction. Consult physician.
How to Take
Administer intramuscularly (IM) into a large muscle mass or intravenously (IV) slowly over at least 2 minutes. For IV administration, it may be diluted with normal saline.
Mechanism of Action
Tiemis acts as a competitive antagonist at H1 receptors, particularly in the vestibular system and chemoreceptor trigger zone (CTZ) in the brain, reducing the excitability of these areas which are involved in nausea and vomiting. It also exhibits anticholinergic properties.
Pharmacokinetics
Onset
15-30 minutes
Excretion
Mainly excreted in urine as metabolites, with a small portion excreted unchanged.
Half life
Approximately 4-6 hours
Absorption
Rapidly absorbed following intramuscular (IM) administration; onset of action typically within 15-30 minutes.
Metabolism
Primarily metabolized in the liver via hydroxylation and glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to Tiemis or any component of the formulation
- Acute angle-closure glaucoma
- Prostatic hypertrophy with urinary retention
- Newborns or premature infants
Drug Interactions
CNS Depressants (e.g., alcohol, benzodiazepines, opioids)
Potentiates sedative effects, leading to increased drowsiness and CNS depression.
Anticholinergic Drugs (e.g., tricyclic antidepressants, atropine)
Increased risk of anticholinergic side effects like dry mouth, blurred vision, and urinary retention.
Storage
Store below 30°C. Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms may include severe drowsiness, coma, convulsions, hallucinations, and cardiac arrhythmias. Management involves supportive care, maintaining airway, gastric lavage if oral ingestion, and symptomatic treatment. Naloxone may be considered for severe CNS depression.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed and the benefit outweighs the risk. Excreted into breast milk, caution is advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Patented by manufacturer
Clinical Trials
Clinical trials have demonstrated the efficacy of Tiemis 5 mg Injection in reducing acute nausea and vomiting in various patient populations, with a favorable safety profile when used as directed.
Lab Monitoring
- No routine lab monitoring is generally required for short-term use. Monitor vital signs during intravenous administration.
Doctor Notes
- Monitor patients for excessive sedation, especially when co-administered with other CNS depressants.
- Assess for underlying causes of nausea/vomiting before initiating treatment.
- Caution in elderly and patients with pre-existing conditions like glaucoma or prostatic hyperplasia.
Patient Guidelines
- Do not drive or operate heavy machinery if you feel drowsy or dizzy.
- Avoid alcohol while on this medication.
- Inform your doctor about all other medications you are taking.
- Report any severe or unusual side effects to your healthcare provider.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Tiemis 5 mg Injection can cause drowsiness and impaired judgment. Patients should be advised not to drive or engage in activities requiring mental alertness until they know how the drug affects them.
Lifestyle Advice
- Stay hydrated, especially if experiencing nausea and vomiting.
- Avoid strong odors or foods that trigger nausea.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.