Tifsi
Generic Name
Tifsidol Hydrochloride
Manufacturer
MediCare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tifsi 1 mg syrup | ৳ 50.00 | N/A |
Description
Overview of the medicine
Tifsi 1 mg Syrup contains Tifsidol, a novel non-sedating H1 antihistamine, used to relieve symptoms associated with seasonal and perennial allergic rhinitis and chronic idiopathic urticaria.
Uses & Indications
Dosage
Adults
Adults and adolescents 12 years and older: 10 ml (2 mg) once daily.
Elderly
No dosage adjustment generally required, but caution advised.
Renal_impairment
Mild to moderate renal impairment: 5 ml (1 mg) once daily. Severe impairment: Not recommended.
How to Take
Administer orally, with or without food. Use a measuring spoon or oral syringe for accurate dosing.
Mechanism of Action
Tifsidol selectively antagonizes peripheral H1 receptors, thereby inhibiting the effects of histamine and reducing allergic symptoms such as sneezing, rhinorrhea, pruritus, and watery eyes.
Pharmacokinetics
Onset
Within 30-60 minutes
Excretion
Mainly excreted through urine (60%) and feces (40%) as metabolites and unchanged drug.
Half life
Approximately 12-15 hours
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations achieved within 1-2 hours.
Metabolism
Primarily metabolized in the liver via CYP3A4 into active and inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Tifsidol or any component of the formulation
- Severe renal impairment
- Children under 6 months of age
Drug Interactions
CNS Depressants (e.g., alcohol, sedatives)
Increased risk of CNS depression.
CYP3A4 Inhibitors (e.g., ketoconazole, erythromycin)
May increase Tifsidol plasma levels.
Storage
Store below 30°C, protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, tachycardia, and headache. Treatment is symptomatic and supportive; no specific antidote. Gastric lavage or activated charcoal may be considered soon after ingestion.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk, caution advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to Tifsidol or any component of the formulation
- Severe renal impairment
- Children under 6 months of age
Drug Interactions
CNS Depressants (e.g., alcohol, sedatives)
Increased risk of CNS depression.
CYP3A4 Inhibitors (e.g., ketoconazole, erythromycin)
May increase Tifsidol plasma levels.
Storage
Store below 30°C, protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, tachycardia, and headache. Treatment is symptomatic and supportive; no specific antidote. Gastric lavage or activated charcoal may be considered soon after ingestion.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk, caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Patent pending
Clinical Trials
Multiple phase III clinical trials demonstrated Tifsidol's efficacy and safety in allergic rhinitis and chronic idiopathic urticaria across diverse patient populations.
Lab Monitoring
- Liver function tests (in patients with hepatic impairment)
- Renal function tests (in patients with renal impairment)
Doctor Notes
- Emphasize non-sedating profile to patients.
- Advise caution in patients with hepatic or severe renal impairment.
- Review concomitant medications for potential interactions, especially CYP3A4 inhibitors.
Patient Guidelines
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Avoid alcohol while taking this medicine.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Although Tifsi is a non-sedating antihistamine, individual responses may vary. Caution is advised when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Identify and avoid known allergens.
- Maintain good indoor air quality.
- Stay hydrated.
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