Tigirate
Generic Name
Tigecycline
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tigirate 200 mg capsule | ৳ 7.06 | ৳ 70.60 |
Description
Overview of the medicine
Tigirate 200 mg capsule is an antibiotic containing Tigecycline, a glycylcycline, which is effective against a broad range of Gram-positive and Gram-negative bacteria, including multidrug-resistant strains. While Tigecycline is typically administered intravenously, this specific formulation is presented as an oral capsule. It is used for treating complicated skin and soft tissue infections (cSSTI) and complicated intra-abdominal infections (cIAI) caused by susceptible microorganisms.
Uses & Indications
Dosage
Adults
The typical recommended dose for Tigirate 200 mg capsule is one capsule (200 mg) orally once daily. Duration of treatment should be determined by the physician based on the infection type and severity.
Elderly
No dose adjustment is required for elderly patients. However, caution should be exercised due to potentially decreased physiological function.
Renal_impairment
No dose adjustment is required for patients with renal impairment (creatinine clearance ≥ 30 mL/min). For severe impairment (CrCl < 30 mL/min), specific data for 200 mg oral capsule may be limited, but generally, Tigecycline does not require dose adjustment in renal insufficiency for its IV form.
How to Take
Take the capsule orally with a glass of water, with or without food. It is important to complete the full course of treatment as prescribed by your doctor, even if symptoms improve.
Mechanism of Action
Tigecycline is a bacteriostatic antibiotic that inhibits protein synthesis by binding to the 30S ribosomal subunit in bacteria, preventing the association of aminoacyl-tRNA with the ribosome's A site. This action disrupts bacterial growth and replication.
Pharmacokinetics
Onset
Onset of action is relatively rapid upon achieving therapeutic concentrations, typically within hours.
Excretion
Primarily excreted unchanged via biliary/fecal route (approximately 59%), with a smaller portion excreted renally (approximately 33%).
Half life
Approximately 27-48 hours, allowing for once-daily dosing (for a 200 mg capsule, if effective oral absorption is achieved).
Absorption
Oral bioavailability of tigecycline is generally very low. For a 200 mg capsule, special formulation may be required to ensure adequate systemic absorption. Information for an oral 200 mg capsule is limited.
Metabolism
Undergoes minimal metabolism; primarily glucuronidation and epimerization.
Side Effects
Contraindications
- Known hypersensitivity to tigecycline or to any of the tetracycline class antibiotics.
- Children under 8 years of age (due to potential for permanent tooth discoloration and enamel hypoplasia, a class effect of tetracyclines).
Drug Interactions
Warfarin
May prolong prothrombin time (PT) and increase INR. Monitor coagulation parameters closely.
Cyclosporine
Coadministration with Tigecycline may increase serum cyclosporine levels; monitor cyclosporine levels.
Oral contraceptives
May reduce the efficacy of oral contraceptives; advise patients to use alternative or additional contraception.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, discontinue Tigirate and initiate symptomatic and supportive measures. Tigecycline is not significantly removed by hemodialysis or peritoneal dialysis.
Pregnancy & Lactation
Pregnancy Category D: Tigecycline can cause fetal harm when administered to a pregnant woman. It should not be used in pregnant women unless the potential benefit outweighs the potential risk to the fetus. It is unknown whether tigecycline is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Hospitals and specialized pharmacies
Approval Status
Approved by major regulatory authorities for specific indications (usually IV form)
Patent Status
Generic versions of Tigecycline are available; brand-specific patents may vary.
Clinical Trials
Clinical trials for Tigecycline primarily focus on its intravenous formulation. Any oral 200 mg capsule formulation would require specific trials to establish efficacy and safety for oral administration.
Lab Monitoring
- Liver function tests (ALT, AST, bilirubin) at baseline and periodically during treatment.
- Renal function tests (creatinine, BUN) if clinically indicated.
- Complete blood count (CBC) to monitor for thrombocytopenia.
Doctor Notes
- Emphasize the Black Box Warning regarding increased mortality with Tigecycline and discuss with patients.
- Reserve Tigecycline for infections where alternative treatments are not appropriate due to resistance or other factors.
- Monitor liver function tests and coagulation parameters during treatment.
Patient Guidelines
- Take Tigirate exactly as prescribed by your doctor and complete the entire course of medication.
- Report any severe or persistent side effects, especially severe abdominal pain, nausea, or vomiting, to your doctor immediately.
- Be aware of the Black Box Warning regarding increased mortality and discuss any concerns with your healthcare provider.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Tigirate may cause dizziness, lightheadedness, or visual disturbances. Patients should be cautioned about operating machinery or driving until they know how the medication affects them.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Avoid alcohol consumption during treatment as it may exacerbate some side effects.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.