Timonate
Generic Name
Timonate
Manufacturer
PharmaCare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| timonate 5 mg injection | ৳ 25.00 | N/A |
Description
Overview of the medicine
Timonate 5 mg Injection is an antiemetic used for the short-term treatment of nausea and vomiting, especially post-operative or chemotherapy-induced nausea and vomiting.
Uses & Indications
Dosage
Adults
5-10 mg intramuscularly or intravenously, 3-4 times daily as needed. Maximum daily dose 30 mg.
Elderly
Initial dose of 5 mg, then adjust based on response and renal function. Use with caution.
Renal_impairment
Reduce dose by 50% for creatinine clearance <30 mL/min.
How to Take
Administer intramuscularly or intravenously. For intravenous administration, inject slowly over at least 2 minutes. Can be diluted in saline or dextrose solutions.
Mechanism of Action
Timonate acts as a selective dopamine D2 receptor antagonist in the chemoreceptor trigger zone (CTZ) and the gastrointestinal tract, thereby blocking emetic stimuli.
Pharmacokinetics
Onset
Within 15-30 minutes (intramuscular), 3-5 minutes (intravenous).
Excretion
Mainly excreted via urine, with a small portion in feces.
Half life
Approximately 4-6 hours.
Absorption
Rapidly absorbed after intramuscular administration, reaching peak plasma concentrations within 30 minutes.
Metabolism
Primarily metabolized in the liver via CYP450 enzymes.
Side Effects
Contraindications
- Known hypersensitivity to Timonate or any component.
- Phaeochromocytoma (due to risk of hypertensive crisis).
- Epilepsy or other conditions predisposing to convulsions.
- History of tardive dyskinesia from neuroleptics or metoclopramide.
- Severe hepatic impairment.
Drug Interactions
Anticholinergics
May antagonize the prokinetic effect of Timonate.
Dopaminergic agonists (e.g., bromocriptine)
Timonate may reduce their effect.
CNS depressants (e.g., opioids, benzodiazepines)
May enhance sedative effects.
Drugs that prolong QT interval (e.g., certain antiarrhythmics, antidepressants)
Increased risk of cardiac arrhythmias.
Storage
Store below 30°C. Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, disorientation, and extrapyramidal reactions. In severe cases, cardiac arrhythmias (including QT prolongation) and seizures may occur. Treatment is symptomatic and supportive. Anticholinergic drugs may be used for extrapyramidal symptoms. Monitor cardiac rhythm.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefit outweighs the potential risk. Excreted in breast milk, so caution should be exercised in nursing mothers and consider alternatives or temporary cessation of breastfeeding.
Side Effects
Contraindications
- Known hypersensitivity to Timonate or any component.
- Phaeochromocytoma (due to risk of hypertensive crisis).
- Epilepsy or other conditions predisposing to convulsions.
- History of tardive dyskinesia from neuroleptics or metoclopramide.
- Severe hepatic impairment.
Drug Interactions
Anticholinergics
May antagonize the prokinetic effect of Timonate.
Dopaminergic agonists (e.g., bromocriptine)
Timonate may reduce their effect.
CNS depressants (e.g., opioids, benzodiazepines)
May enhance sedative effects.
Drugs that prolong QT interval (e.g., certain antiarrhythmics, antidepressants)
Increased risk of cardiac arrhythmias.
Storage
Store below 30°C. Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, disorientation, and extrapyramidal reactions. In severe cases, cardiac arrhythmias (including QT prolongation) and seizures may occur. Treatment is symptomatic and supportive. Anticholinergic drugs may be used for extrapyramidal symptoms. Monitor cardiac rhythm.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefit outweighs the potential risk. Excreted in breast milk, so caution should be exercised in nursing mothers and consider alternatives or temporary cessation of breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Available in hospitals and pharmacies
Approval Status
Approved by DGDA
Patent Status
Off-patent
Clinical Trials
Several clinical trials have demonstrated Timonate's efficacy and safety in preventing and treating post-operative and chemotherapy-induced nausea and vomiting, showing superiority over placebo in most studies.
Lab Monitoring
- Electrolyte levels (potassium, magnesium) if there is risk of QT prolongation.
- Renal function (for dose adjustment in impaired patients).
- ECG monitoring in patients with pre-existing cardiac conditions or those on concomitant QT-prolonging drugs.
Doctor Notes
- Consider patient's cardiac history due to potential QT prolongation risk.
- Monitor for signs of extrapyramidal symptoms, especially in pediatric and elderly patients, and consider dose reduction or discontinuation if symptoms occur.
- Assess renal function for appropriate dose adjustment.
Patient Guidelines
- Report any unusual side effects promptly to your doctor.
- Avoid driving or operating machinery if experiencing drowsiness or dizziness.
- Inform your doctor about all other medications, including over-the-counter drugs and herbal supplements.
- Do not exceed the prescribed dose or duration of treatment.
Missed Dose Advice
As this is an on-demand injection, a missed dose is unlikely. If administered regularly and a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not double the dose.
Driving Precautions
Timonate 5 mg Injection may cause drowsiness, dizziness, or blurred vision. Patients should be advised not to drive or operate machinery until they know how Timonate affects them.
Lifestyle Advice
- Stay hydrated, especially if experiencing vomiting.
- Eat small, frequent meals if nausea is present.
- Avoid alcohol as it may increase drowsiness and other side effects.
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