Tino
Generic Name
Tinoprofen
Manufacturer
Alpha Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tino 50 mg tablet | ৳ 4.00 | ৳ 40.00 |
Description
Overview of the medicine
Tino 50 mg Tablet contains Tinoprofen, a non-steroidal anti-inflammatory drug (NSAID) used for pain relief and reducing inflammation. It is indicated for various conditions including arthritis, muscle pain, and dysmenorrhea.
Uses & Indications
Dosage
Adults
50 mg two to three times daily, adjusted according to patient response and tolerability. Maximum recommended dose is 150 mg/day.
Elderly
Lower doses (e.g., 50 mg once or twice daily) may be required due to increased sensitivity to adverse effects. Careful monitoring for renal and gastrointestinal adverse effects is essential.
Renal_impairment
For moderate impairment (CrCl 30-60 mL/min), consider reducing the dose or increasing the dosing interval. For severe impairment (CrCl <30 mL/min), use is generally not recommended or requires significant dose reduction and strict monitoring.
How to Take
Take orally, preferably with food or milk to reduce gastrointestinal upset. Swallow the tablet whole with a glass of water; do not crush, chew, or break.
Mechanism of Action
Tinoprofen inhibits cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Mainly renal as metabolites (60-70%) and a small amount of unchanged drug (less than 10%).
Half life
Approximately 2-4 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, reaching peak plasma concentrations within 1-2 hours.
Metabolism
Primarily hepatic via CYP enzymes, with extensive metabolism to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Tinoprofen or other NSAIDs (e.g., aspirin, ibuprofen)
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe renal or hepatic impairment
- Severe uncontrolled heart failure
- Third trimester of pregnancy (due to risk of premature closure of ductus arteriosus)
- History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs
- Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
Drug Interactions
Lithium
Increased lithium plasma levels and potential toxicity due to reduced renal clearance of lithium.
Methotrexate
Increased methotrexate toxicity due to reduced renal clearance.
Warfarin and other anticoagulants
Increased risk of bleeding due to inhibition of platelet aggregation and potential displacement from plasma protein binding.
SSRIs (Selective Serotonin Reuptake Inhibitors)
Increased risk of gastrointestinal bleeding.
Diuretics (e.g., Furosemide, Hydrochlorothiazide)
Reduced natriuretic and antihypertensive effect, increased risk of renal impairment.
ACE Inhibitors and Angiotensin Receptor Blockers (ARBs)
Reduced antihypertensive effect and increased risk of renal impairment, particularly in volume-depleted or elderly patients.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, drowsiness, dizziness, and headache. More severe symptoms can include gastrointestinal bleeding, acute renal failure, coma, and convulsions. Management is primarily supportive. Gastric lavage or activated charcoal may be considered within an hour of ingestion. Monitor vital signs and provide symptomatic treatment.
Pregnancy & Lactation
Pregnancy Category C in first and second trimesters, D in third trimester. Avoid in the third trimester of pregnancy due to the risk of premature closure of the fetal ductus arteriosus. Use with caution during the first and second trimesters only if the potential benefit justifies the potential risk to the fetus. Tinoprofen is excreted in breast milk; therefore, use with caution during lactation, and a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the manufacturing date, when stored under recommended conditions.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent Pending
Clinical Trials
Tinoprofen has undergone successful Phase I and Phase II clinical trials demonstrating its efficacy and safety profile. Phase III trials are currently ongoing for broader indications and long-term safety evaluation.
Lab Monitoring
- Renal function tests (serum creatinine, BUN) periodically, especially in patients with pre-existing renal impairment or those on long-term therapy.
- Liver function tests (ALT, AST) periodically, particularly with long-term use.
- Complete blood count (CBC) to monitor for anemia and other hematological abnormalities with extended therapy.
- Blood pressure monitoring regularly.
Doctor Notes
- Thoroughly assess patient's cardiovascular and gastrointestinal risk factors before initiating Tinoprofen therapy, especially for long-term use.
- Monitor renal function, liver enzymes, and blood pressure periodically in patients receiving chronic Tinoprofen treatment.
- Advise patients to report any unusual bleeding, persistent abdominal pain, swelling, or changes in urine output promptly.
- Prescribe the lowest effective dose for the shortest possible duration consistent with individual patient treatment goals to minimize potential risks.
- Caution against concomitant use with other NSAIDs, aspirin (unless low-dose for cardiac protection), anticoagulants, and certain antihypertensives.
Patient Guidelines
- Take Tino 50 mg Tablet exactly as prescribed by your doctor.
- Do not exceed the recommended dose or duration of treatment to minimize risks of side effects.
- Report any signs of stomach bleeding (e.g., black or tarry stools, coffee-ground vomit) or severe abdominal pain immediately to your doctor.
- Avoid taking other NSAIDs or aspirin without consulting your doctor.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
- Consult your doctor if you experience swelling, sudden weight gain, or unusual fatigue.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Tinoprofen may cause dizziness, drowsiness, or visual disturbances in some individuals. Patients should be cautioned about driving or operating machinery until they are reasonably certain that Tinoprofen does not adversely affect their ability to perform such activities.
Lifestyle Advice
- Avoid or limit alcohol consumption while taking Tinoprofen, as it can increase the risk of gastrointestinal side effects.
- Maintain a healthy diet and stay well-hydrated.
- If you have a history of stomach problems, discuss with your doctor about taking a stomach protectant along with Tinoprofen.
- Engage in regular, moderate exercise if your condition allows, and as advised by your doctor.
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