Tioxil
Generic Name
Tiotropium Bromide
Manufacturer
Renata Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tioxil 60 mg capsule | ৳ 10.00 | ৳ 80.00 |
Description
Overview of the medicine
Tioxil (Tiotropium Bromide) is a long-acting anticholinergic bronchodilator used to manage chronic obstructive pulmonary disease (COPD).
Uses & Indications
Dosage
Adults
One 18 mcg inhalation capsule once daily using the HandiHaler device.
Elderly
No dosage adjustment required.
Renal_impairment
Use with caution in severe renal impairment (creatinine clearance < 50 mL/min).
How to Take
For oral inhalation only. Do not swallow the capsule. Use only with the HandiHaler device. Puncture the capsule and inhale contents deeply.
Mechanism of Action
Tiotropium is a long-acting, specific muscarinic receptor antagonist, often referred to as an anticholinergic. It acts by inhibiting M3 muscarinic receptors on airway smooth muscle, leading to bronchodilation.
Pharmacokinetics
Onset
Within 30 minutes
Excretion
Primarily excreted unchanged in urine (about 75% of IV dose). A small portion is excreted via feces.
Half life
Terminal elimination half-life is 5-6 days following multiple once-daily inhalations.
Absorption
Low systemic absorption following inhalation. Oral bioavailability is 2-3%.
Metabolism
Partially metabolized by ester hydrolysis to an alcohol and a carboxylic acid derivative. Cytochrome P450 enzymes play a minor role.
Side Effects
Contraindications
- Hypersensitivity to tiotropium, ipratropium, or any components
- Acute bronchospasm (not for rescue therapy)
Drug Interactions
Other anticholinergics
Avoid concomitant use due to potential additive effects.
Sympathomimetics/Xanthines/Steroids
May enhance bronchodilator effect.
Storage
Store at room temperature (below 30°C). Protect from moisture and light. Keep out of reach of children.
Overdose
High doses may lead to anticholinergic signs and symptoms such as dry mouth, blurred vision, tachycardia. Symptomatic and supportive treatment.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to tiotropium, ipratropium, or any components
- Acute bronchospasm (not for rescue therapy)
Drug Interactions
Other anticholinergics
Avoid concomitant use due to potential additive effects.
Sympathomimetics/Xanthines/Steroids
May enhance bronchodilator effect.
Storage
Store at room temperature (below 30°C). Protect from moisture and light. Keep out of reach of children.
Overdose
High doses may lead to anticholinergic signs and symptoms such as dry mouth, blurred vision, tachycardia. Symptomatic and supportive treatment.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, check product specific labeling.
Availability
Pharmacies and hospitals nationwide
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Original patent expired; generic versions available. Formulations may have new patents.
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated efficacy and safety in COPD patients, including significant improvements in lung function and reduction in exacerbations.
Lab Monitoring
- Regular assessment of lung function (e.g., FEV1)
- Monitor for anticholinergic side effects
Doctor Notes
- Emphasize correct HandiHaler technique to patients.
- Differentiate from short-acting bronchodilators for acute relief.
- Assess for anticholinergic side effects regularly.
Patient Guidelines
- Do not use for acute breathing problems.
- Ensure correct inhalation technique with HandiHaler device.
- Report any worsening of breathing or eye pain/discomfort immediately.
Missed Dose Advice
If a dose is missed, take it as soon as possible. Do not take two doses at once. Continue with the next scheduled dose.
Driving Precautions
May cause dizziness or blurred vision, which could impair driving or operating machinery. Exercise caution.
Lifestyle Advice
- Avoid smoking
- Regular exercise as advised by doctor
- Maintain good hydration
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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