Tirza
Generic Name
Diclofenac Sodium
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tirza 75 mg injection | ৳ 3,500.00 | N/A |
Description
Overview of the medicine
Tirza 75 mg Injection contains Diclofenac Sodium, a non-steroidal anti-inflammatory drug (NSAID) used for acute pain and inflammation. It is administered via intramuscular injection and provides rapid relief from moderate to severe pain.
Uses & Indications
Dosage
Adults
Usually 75 mg (1 ampoule) once daily, by deep intramuscular injection into the gluteal muscle. In severe cases, up to 75 mg twice daily may be given, but for no more than 2 days. Total daily dose should not exceed 150 mg.
Elderly
Use with caution; lower doses or longer intervals may be necessary due to increased risk of side effects, especially gastrointestinal bleeding.
Renal_impairment
Use with caution. Avoid in severe renal impairment. In moderate impairment, dosage adjustment may be needed, and monitoring of renal function is advised.
How to Take
For deep intramuscular injection into the gluteal muscle. Intravenous administration should only be done as a slow infusion after dilution.
Mechanism of Action
Diclofenac works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Within 15-30 minutes.
Excretion
Approximately 60% eliminated in the urine as metabolites and less than 1% as unchanged drug; the remainder is eliminated via bile and feces.
Half life
Approximately 1-2 hours (terminal half-life of parent compound), but a longer half-life for its active metabolites (up to 20 hours).
Absorption
Rapidly and completely absorbed after intramuscular administration. Peak plasma concentrations are reached within 10-30 minutes.
Metabolism
Extensively metabolized in the liver, primarily by hydroxylation and glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to diclofenac, aspirin, or other NSAIDs
- Active gastrointestinal ulceration, bleeding, or perforation
- Severe heart failure, severe renal failure, or severe hepatic failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Lithium and Methotrexate
Increased plasma levels of lithium and methotrexate.
Diuretics and ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
SSRIs (Selective Serotonin Reuptake Inhibitors)
Increased risk of gastrointestinal bleeding.
Storage
Store below 30°C. Protect from light. Do not freeze.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management is symptomatic and supportive, including gastric decontamination (if recent ingestion) and monitoring vital signs.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters); Category D (third trimester). Should be avoided in the third trimester due to potential adverse effects on the fetus (e.g., premature closure of ductus arteriosus). Use with caution during lactation; diclofenac is excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to diclofenac, aspirin, or other NSAIDs
- Active gastrointestinal ulceration, bleeding, or perforation
- Severe heart failure, severe renal failure, or severe hepatic failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Lithium and Methotrexate
Increased plasma levels of lithium and methotrexate.
Diuretics and ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
SSRIs (Selective Serotonin Reuptake Inhibitors)
Increased risk of gastrointestinal bleeding.
Storage
Store below 30°C. Protect from light. Do not freeze.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management is symptomatic and supportive, including gastric decontamination (if recent ingestion) and monitoring vital signs.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters); Category D (third trimester). Should be avoided in the third trimester due to potential adverse effects on the fetus (e.g., premature closure of ductus arteriosus). Use with caution during lactation; diclofenac is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies, hospitals, and clinics
Approval Status
Approved by regulatory authorities worldwide
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensively studied and clinically proven for its efficacy and safety in various pain and inflammatory conditions.
Lab Monitoring
- Complete blood count (CBC) with prolonged use
- Liver function tests (LFTs) periodically
- Renal function tests (serum creatinine, BUN) periodically
Doctor Notes
- Administer deep intramuscularly to minimize injection site reactions.
- Monitor renal function, hepatic function, and blood pressure with prolonged use.
- Carefully weigh risks vs. benefits in patients with pre-existing cardiovascular or gastrointestinal conditions.
Patient Guidelines
- Do not exceed the prescribed dose or duration of treatment.
- Report any unusual bleeding, persistent stomach pain, or skin rash immediately.
- Avoid alcohol during treatment to minimize gastrointestinal side effects.
Missed Dose Advice
If you miss a dose, administer it as soon as you remember, unless it is almost time for your next scheduled dose. Do not double the dose to catch up.
Driving Precautions
May cause dizziness or visual disturbances. Patients should be advised to avoid driving or operating machinery if they experience these side effects.
Lifestyle Advice
- Stay hydrated
- Avoid strenuous activities if feeling dizzy
- Maintain a balanced diet
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