Tizaro
Generic Name
Tizaro 75 mg Injection
Manufacturer
Acme Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tizaro 75 mg injection | ৳ 2,800.00 | N/A |
Description
Overview of the medicine
Tizaro 75 mg Injection is an NSAID used for rapid relief from acute pain, inflammation, and fever. It is administered via intramuscular route.
Uses & Indications
Dosage
Adults
Usually 75 mg once daily by deep intramuscular injection. In severe cases, 75 mg twice daily (morning and evening) can be given, preferably at different sites. Maximum daily dose is 150 mg.
Elderly
No specific dose adjustment is usually required, but caution is advised due to increased risk of side effects.
Renal_impairment
Use with caution; dose reduction may be necessary in severe impairment. Not recommended for patients with advanced renal disease.
How to Take
Administer by deep intramuscular (IM) injection. For IV administration, it must be diluted and infused slowly under strict medical supervision.
Mechanism of Action
It inhibits cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Within 15-30 minutes for pain relief.
Excretion
Mainly through urine (approx. 60%) and bile (approx. 35%).
Half life
Approximately 1.5-2 hours.
Absorption
Rapidly and completely absorbed after intramuscular administration, reaching peak plasma concentrations within 10-30 minutes.
Metabolism
Primarily hepatic, undergoing hydroxylation and glucuronidation.
Side Effects
Contraindications
- Known hypersensitivity to the active substance or any excipients, or to other NSAIDs (e.g., aspirin)
- Active or history of recurrent peptic ulcer/hemorrhage
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- Coronary Artery Bypass Graft (CABG) surgery
Drug Interactions
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Lithium and Methotrexate
Increased plasma levels of lithium and methotrexate.
Diuretics and ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Warfarin and other anticoagulants
Increased risk of bleeding.
Storage
Store below 30°C. Protect from light. Do not freeze.
Overdose
Symptoms may include nausea, vomiting, epigastric pain, gastrointestinal hemorrhage, diarrhea, disorientation, excitation, coma, drowsiness, tinnitus, and syncope. Acute renal failure and liver damage are possible. Management is symptomatic and supportive.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus. Use with caution during first and second trimesters only if potential benefits outweigh risks. Excreted in breast milk in small amounts; use with caution during lactation.
Side Effects
Contraindications
- Known hypersensitivity to the active substance or any excipients, or to other NSAIDs (e.g., aspirin)
- Active or history of recurrent peptic ulcer/hemorrhage
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- Coronary Artery Bypass Graft (CABG) surgery
Drug Interactions
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Lithium and Methotrexate
Increased plasma levels of lithium and methotrexate.
Diuretics and ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Warfarin and other anticoagulants
Increased risk of bleeding.
Storage
Store below 30°C. Protect from light. Do not freeze.
Overdose
Symptoms may include nausea, vomiting, epigastric pain, gastrointestinal hemorrhage, diarrhea, disorientation, excitation, coma, drowsiness, tinnitus, and syncope. Acute renal failure and liver damage are possible. Management is symptomatic and supportive.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus. Use with caution during first and second trimesters only if potential benefits outweigh risks. Excreted in breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of NSAIDs like Tizaro for acute pain and inflammation management. Post-marketing surveillance continues to monitor long-term safety.
Lab Monitoring
- Regular monitoring of renal function (creatinine, BUN) with long-term use.
- Liver function tests (ALT, AST) periodically, especially in patients with pre-existing liver conditions.
- Complete blood count (CBC) to monitor for anemia or other blood dyscrasias.
Doctor Notes
- Assess patient's cardiovascular and gastrointestinal risk factors before prescribing, especially for elderly patients.
- Monitor renal function, particularly in patients with pre-existing impairment or those on concomitant nephrotoxic drugs.
- Administer the lowest effective dose for the shortest duration necessary to minimize adverse effects.
Patient Guidelines
- This injection is usually administered by a doctor or nurse in a healthcare setting.
- Report any severe pain, swelling, or redness at the injection site immediately.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
Since this is an injection administered by a healthcare professional, missed doses are unlikely. If an appointment is missed, contact your doctor to reschedule.
Driving Precautions
May cause dizziness or visual disturbances. Patients should be cautioned against driving or operating machinery if they experience such effects.
Lifestyle Advice
- Avoid alcohol consumption, especially if you have a history of gastrointestinal problems.
- Maintain adequate hydration while on this medication.
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