Tkof
Generic Name
Levodropropizine
Manufacturer
ABC Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tkof 75 mg syrup | ৳ 78.00 | N/A |
Description
Overview of the medicine
Tkof 75 mg syrup contains Levodropropizine, a non-opioid antitussive agent used for the symptomatic relief of non-productive cough. It primarily acts peripherally on the tracheobronchial tree to reduce cough reflex.
Uses & Indications
Dosage
Adults
10 ml (75 mg) three times daily
Elderly
No special dosage adjustment required, but caution is advised in elderly patients with severe renal impairment.
Renal_impairment
Caution recommended. Dosage reduction might be necessary in severe renal impairment (creatinine clearance < 35 mL/min).
How to Take
For oral use. Can be taken with or without food. Use the provided measuring cup or spoon for accurate dosing.
Mechanism of Action
Levodropropizine is a non-opioid antitussive agent that acts peripherally by inhibiting the afferent pathways of the cough reflex, potentially through modulation of sensory C-fibres in the tracheobronchial tree. It does not exert any central depressant activity.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly excreted via urine in conjugated form.
Half life
Approximately 1-2 hours
Absorption
Rapidly absorbed from the gastrointestinal tract. Peak plasma levels achieved within 1-2 hours.
Metabolism
Extensively metabolized, primarily by glucuronidation. No active metabolites.
Side Effects
Contraindications
- Hypersensitivity to Levodropropizine or any excipients
- Productive cough (with phlegm)
- Severe renal impairment
- Pregnancy and lactation
Drug Interactions
Alcohol
Concurrent consumption may increase CNS depressant effects.
Sedatives
Concurrent use may enhance sedative effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, gastrointestinal disturbances. Management is symptomatic and supportive. Gastric lavage may be considered.
Pregnancy & Lactation
Contraindicated during pregnancy and lactation due to lack of sufficient safety data.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in all pharmacies
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Several clinical trials have demonstrated the efficacy and safety of Levodropropizine in reducing cough frequency and severity in patients with non-productive cough.
Lab Monitoring
- No specific lab monitoring required for routine use.
Doctor Notes
- Advise patients on appropriate cough hygiene.
- Differentiate between productive and non-productive cough before prescribing.
- Monitor for signs of CNS depression, especially with concomitant use of sedatives or alcohol.
Patient Guidelines
- Do not use for productive cough.
- Do not exceed the recommended dose.
- Consult your doctor if cough persists for more than 7 days.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause drowsiness or dizziness. Patients should be advised to exercise caution when driving or operating machinery.
Lifestyle Advice
- Maintain good hydration.
- Avoid irritants like smoke and dust.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.