Adults

Mild to moderate infection: 1-2 drops into the affected eye(s) every 4 hours. Severe infection: 2 drops into the affected eye(s) every hour until improvement, then reduce frequency.

Elderly

Same as adults. No specific dosage adjustment is generally required.

Renal_impairment

No dosage adjustment necessary for topical ophthalmic use due to minimal systemic absorption.

Onset

Rapid onset of action, typically within minutes to hours for symptomatic relief.

Excretion

If systemically absorbed (which is minimal), it is primarily excreted unchanged in the urine. Local elimination from ocular tissues.

Half life

Systemic half-life is not clinically significant due to minimal absorption. Local half-life in ocular tissues varies.

Absorption

Minimal systemic absorption after topical ocular administration. High concentrations are achieved in ocular tissues.

Metabolism

Not significantly metabolized in the eye or systemically after topical application.

Systemic aminoglycosides

Although systemic absorption is minimal, theoretical risk of increased systemic toxicity (e.g., ototoxicity, nephrotoxicity) if used concurrently with systemic aminoglycosides, especially in patients with impaired renal function.

Other topical ophthalmic medications

If using multiple eye drops, administer them at least 5 minutes apart to prevent wash-out.