Toco
Generic Name
Alpha-Tocopherol (Vitamin E)
Manufacturer
Generic Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| toco 375 mg injection | ৳ 3,800.00 | N/A |
Description
Overview of the medicine
Toco-375 mg Injection contains Alpha-Tocopherol, a form of Vitamin E. It is a fat-soluble vitamin and a powerful antioxidant, crucial for protecting cell membranes from oxidative damage. This injection is used to treat and prevent Vitamin E deficiency, particularly in conditions involving malabsorption or increased requirements.
Uses & Indications
Dosage
Adults
For severe deficiency: 50-100 mg intramuscularly, 2-3 times per week, or as directed by a physician. Dosage varies based on the specific condition and severity of deficiency.
Elderly
No specific dosage adjustment required, but monitor for underlying conditions and drug interactions.
Renal_impairment
No specific dosage adjustment recommended, as it's primarily excreted via bile.
How to Take
For intramuscular (IM) injection only. Administer deeply into a large muscle. Do not administer intravenously.
Mechanism of Action
Alpha-Tocopherol is a powerful lipid-soluble antioxidant that protects cellular membranes from damage by reactive oxygen species (free radicals). It scavenges peroxyl radicals, preventing the propagation of free radical chain reactions in polyunsaturated fatty acids.
Pharmacokinetics
Onset
Within hours for therapeutic levels, immediate availability in circulation.
Excretion
Excreted primarily in the feces via bile; a small amount is excreted in the urine as metabolites.
Half life
Highly variable, typically 12-15 hours, but can extend to several days with chronic use or large doses due to extensive tissue storage.
Absorption
Rapidly absorbed into the bloodstream after intramuscular injection, bypassing gastrointestinal absorption. Peak plasma concentrations are reached within hours.
Metabolism
Primarily metabolized in the liver via hydroxylation and oxidation reactions, followed by glucuronidation and sulfation.
Side Effects
Contraindications
- •Hypersensitivity to Alpha-Tocopherol or any component of the injection
- •Caution in patients on anticoagulants or with bleeding disorders
Drug Interactions
Iron supplements
High doses of Vitamin E may interfere with iron absorption or utilization, especially in iron-deficient individuals.
Anticoagulants (e.g., Warfarin)
May enhance the anticoagulant effect, increasing the risk of bleeding. Close monitoring of INR is recommended.
Storage
Store below 30°C, protected from light and moisture. Do not freeze.
Overdose
Vitamin E is generally well-tolerated, even at high doses. Symptoms of very high overdose (e.g., >1000 mg/day long-term) may include gastrointestinal upset, fatigue, weakness, headache, and blurred vision. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Generally considered safe in pregnancy and lactation at recommended doses. However, high doses should be avoided, and use should be under medical supervision.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date when stored correctly.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Off-patent
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