Tolec
Generic Name
Tolperisone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tolec 10 mg tablet | ৳ 10.03 | ৳ 100.30 |
| tolec 30 mg injection | ৳ 55.17 | N/A |
| tolec 60 mg injection | ৳ 95.29 | N/A |
Description
Overview of the medicine
Tolec (Tolperisone) is a centrally acting skeletal muscle relaxant used for the symptomatic treatment of pathologically increased tone of skeletal muscles and muscle spasms. It acts on the central nervous system to inhibit polysynaptic reflex activity.
Uses & Indications
Dosage
Adults
50-150 mg orally, three times daily. The dose should be adjusted according to individual needs and tolerability.
Elderly
No specific dose adjustment is generally required, but caution is advised. Individual dose adjustment may be necessary based on renal/hepatic function.
Renal_impairment
In patients with moderate renal impairment, dose should be reduced and/or interval increased. Not recommended in severe renal impairment.
How to Take
Tolec tablets should be taken orally, preferably after meals, with a glass of water.
Mechanism of Action
Tolperisone acts by stabilizing nerve membranes, thereby reducing the excitability of primary afferent neurons and motor neurons. It inhibits voltage-gated sodium channels and voltage-gated calcium channels, which leads to a reduction in neurotransmitter release and inhibition of polysynaptic reflexes.
Pharmacokinetics
Onset
Onset of action typically occurs within 1-2 hours.
Excretion
Excreted primarily through the kidneys, almost entirely as metabolites.
Half life
Elimination half-life ranges from 1.5 to 2.5 hours.
Absorption
Well absorbed from the gastrointestinal tract, but undergoes extensive first-pass metabolism. Peak plasma concentrations are reached approximately 0.5-1 hour after administration.
Metabolism
Extensively metabolized in the liver, primarily by cytochrome P450 (CYP2D6) enzymes, to inactive metabolites.
Side Effects
Contraindications
- Known hypersensitivity to tolperisone or to any of the excipients.
- Myasthenia gravis.
- Children below 18 years (due to lack of sufficient data).
Drug Interactions
Niflumic acid
Concomitant use with niflumic acid may increase the concentration of niflumic acid, especially in children, requiring caution.
Psychotropic drugs
Caution is advised when co-administering with psychotropic drugs, as potentiation of effects may occur.
Other muscle relaxants
Concurrent use with other centrally acting muscle relaxants may potentiate their effects, requiring dose adjustment.
Storage
Store below 30°C, in a dry place, protected from light. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, dizziness, gastrointestinal symptoms (nausea, vomiting, abdominal pain), and in severe cases, seizures or ataxia. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered within a short period after ingestion.
Pregnancy & Lactation
Pregnancy: Not recommended during pregnancy, especially in the first trimester, unless clearly necessary and potential benefits outweigh risks. Lactation: Not recommended during lactation as it is not known whether tolperisone is excreted in human milk.
Side Effects
Contraindications
- Known hypersensitivity to tolperisone or to any of the excipients.
- Myasthenia gravis.
- Children below 18 years (due to lack of sufficient data).
Drug Interactions
Niflumic acid
Concomitant use with niflumic acid may increase the concentration of niflumic acid, especially in children, requiring caution.
Psychotropic drugs
Caution is advised when co-administering with psychotropic drugs, as potentiation of effects may occur.
Other muscle relaxants
Concurrent use with other centrally acting muscle relaxants may potentiate their effects, requiring dose adjustment.
Storage
Store below 30°C, in a dry place, protected from light. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, dizziness, gastrointestinal symptoms (nausea, vomiting, abdominal pain), and in severe cases, seizures or ataxia. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered within a short period after ingestion.
Pregnancy & Lactation
Pregnancy: Not recommended during pregnancy, especially in the first trimester, unless clearly necessary and potential benefits outweigh risks. Lactation: Not recommended during lactation as it is not known whether tolperisone is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Available in pharmacies across Bangladesh
Approval Status
Approved in Bangladesh and other countries
Patent Status
Generic available, original patent expired
Clinical Trials
Tolperisone has been studied in various clinical trials for its efficacy and safety in muscle spasticity and musculoskeletal pain. Studies have shown it to be effective in reducing muscle tone and improving mobility.
Lab Monitoring
- No specific routine lab monitoring is generally required for Tolperisone.
- Liver and kidney function tests may be considered in patients with pre-existing impairment or during long-term therapy.
Doctor Notes
- Tolperisone is an effective muscle relaxant with a favorable side effect profile compared to benzodiazepine muscle relaxants, as it generally avoids sedation.
- Monitor for hypersensitivity reactions, especially after the first few doses, as these can be severe.
Patient Guidelines
- Take Tolec exactly as prescribed by your doctor.
- Do not stop taking Tolec without consulting your doctor.
- Inform your doctor if you experience any unusual side effects or allergic reactions.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Tolec may cause dizziness, drowsiness, or impaired vision. Patients should be warned not to drive or operate machinery until they are certain that Tolperisone does not adversely affect their ability to do so.
Lifestyle Advice
- Avoid alcohol consumption while taking Tolec, as it may enhance central nervous system depressant effects.
- Maintain a healthy diet and regular exercise routine to support muscle health.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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