Tolfamax
Generic Name
Tolperisone Hydrochloride
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tolfamax 200 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Tolfamax 200 mg Tablet contains Tolperisone Hydrochloride, a centrally acting muscle relaxant used to treat increased muscle tone and spasms associated with various neurological conditions such as stroke, multiple sclerosis, myelopathy, and other spastic conditions. It helps to alleviate pain and improve mobility.
Uses & Indications
Dosage
Adults
Typically 150-450 mg daily in 3 divided doses. For Tolfamax 200 mg, this could mean one tablet 1-2 times daily, adjusted according to individual response and tolerance. Should be taken after meals.
Elderly
Similar to adult dosage, but use with caution and adjust based on renal/hepatic function.
Renal_impairment
Dosage reduction may be necessary in patients with severe renal impairment. Consult a physician.
How to Take
Take the tablet orally after meals to minimize gastrointestinal discomfort and enhance bioavailability. Swallow the tablet whole with a glass of water.
Mechanism of Action
Tolperisone acts on the central nervous system, primarily by inhibiting voltage-gated sodium and calcium channels. It stabilizes neuronal membranes, reducing polysynaptic and monosynaptic reflexes, thereby decreasing muscle hypertonicity and spasticity. It does not cause significant sedation.
Pharmacokinetics
Onset
Within 1-2 hours.
Excretion
Mainly excreted via the kidneys as metabolites.
Half life
Approximately 1.5 - 2.5 hours.
Absorption
Well absorbed from the gastrointestinal tract, but undergoes extensive first-pass metabolism.
Metabolism
Extensively metabolized in the liver, primarily by CYP2D6.
Side Effects
Contraindications
- Hypersensitivity to Tolperisone or any component of the tablet.
- Myasthenia gravis.
- Children (limited data available, generally not recommended).
Drug Interactions
NSAIDs
May increase the concentration of NSAIDs, requiring dose adjustment.
Alcohol
Tolperisone does not enhance the central depressive effect of alcohol.
Other muscle relaxants
Concomitant use may enhance the effect of other muscle relaxants. Consider dose reduction of the other agent.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, and in severe cases, seizures or coma. Treatment is symptomatic and supportive. Gastric lavage may be considered.
Pregnancy & Lactation
Not recommended during pregnancy and lactation unless clearly necessary and the potential benefits outweigh the risks. Consult your doctor.
Side Effects
Contraindications
- Hypersensitivity to Tolperisone or any component of the tablet.
- Myasthenia gravis.
- Children (limited data available, generally not recommended).
Drug Interactions
NSAIDs
May increase the concentration of NSAIDs, requiring dose adjustment.
Alcohol
Tolperisone does not enhance the central depressive effect of alcohol.
Other muscle relaxants
Concomitant use may enhance the effect of other muscle relaxants. Consider dose reduction of the other agent.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, and in severe cases, seizures or coma. Treatment is symptomatic and supportive. Gastric lavage may be considered.
Pregnancy & Lactation
Not recommended during pregnancy and lactation unless clearly necessary and the potential benefits outweigh the risks. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent
Clinical Trials
Tolperisone has undergone numerous clinical trials demonstrating its efficacy and safety as a muscle relaxant, particularly in spasticity management and musculoskeletal pain.
Lab Monitoring
- No routine laboratory monitoring is typically required. In cases of prolonged use or pre-existing hepatic/renal impairment, periodic monitoring of liver and kidney function tests may be advisable.
Doctor Notes
- Counsel patients on potential dizziness/drowsiness and driving precautions.
- Advise patients to take with food to improve absorption and reduce GI upset.
- Monitor for hypersensitivity reactions, especially within the first few weeks of treatment.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Report any unusual or severe side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Tolfamax may cause dizziness or drowsiness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how the medicine affects them.
Lifestyle Advice
- Avoid alcohol consumption as it may increase side effects.
- Be cautious when performing tasks requiring mental alertness, such as driving or operating machinery, especially at the start of treatment.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.