Tolgrin
Generic Name
Tolperisone Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tolgrin 200 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Tolperisone is a centrally acting muscle relaxant used for the symptomatic treatment of spasticity and muscle spasm.
Uses & Indications
Dosage
Adults
Typically 150-450 mg daily, divided into 2-3 doses. For Tolgrin 200 mg tablet, one tablet (200 mg) once or twice daily, depending on individual response and severity.
Elderly
No specific dosage adjustment is usually required, but caution is advised. Start with a lower dose if necessary.
Renal_impairment
Use with caution in moderate renal impairment. Avoid in severe renal impairment (CrCl < 30 mL/min).
How to Take
Take orally, preferably after meals with a glass of water, to reduce gastrointestinal discomfort.
Mechanism of Action
Tolperisone reduces muscle tone via an action on the central nervous system. It primarily acts by stabilizing neuronal membranes and inhibiting voltage-gated sodium and calcium channels, thereby decreasing the excitability of motor neurons and preventing muscle contraction.
Pharmacokinetics
Onset
Within 1-2 hours
Excretion
Mainly excreted by the kidneys, almost exclusively as metabolites.
Half life
Approximately 1.5-2.5 hours
Absorption
Well absorbed from the gastrointestinal tract, but undergoes extensive first-pass metabolism. Bioavailability is approximately 17%.
Metabolism
Extensively metabolized in the liver, primarily by CYP enzymes.
Side Effects
Contraindications
- Hypersensitivity to Tolperisone or any component of the formulation
- Myasthenia gravis
- Children below 18 years (limited data)
Drug Interactions
Methocarbamol
May increase the concentration of Tolperisone.
Other centrally acting muscle relaxants
Use with caution, potential for additive effects.
Non-steroidal anti-inflammatory drugs (NSAIDs)
No significant interactions reported, but caution with concomitant use.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, dizziness, abdominal pain. Management is symptomatic and supportive. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy and lactation only if clearly needed and potential benefits outweigh risks. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Tolperisone or any component of the formulation
- Myasthenia gravis
- Children below 18 years (limited data)
Drug Interactions
Methocarbamol
May increase the concentration of Tolperisone.
Other centrally acting muscle relaxants
Use with caution, potential for additive effects.
Non-steroidal anti-inflammatory drugs (NSAIDs)
No significant interactions reported, but caution with concomitant use.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, dizziness, abdominal pain. Management is symptomatic and supportive. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy and lactation only if clearly needed and potential benefits outweigh risks. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, hospitals
Approval Status
Approved (in various countries, including Bangladesh)
Patent Status
Off-patent, generic available
Clinical Trials
Tolperisone has been studied in numerous clinical trials demonstrating its efficacy and safety in various musculoskeletal conditions.
Lab Monitoring
- No specific routine lab monitoring is required. Liver and renal function tests may be considered in patients with pre-existing impairment.
Doctor Notes
- Assess liver and renal function in patients with pre-existing impairment.
- Advise patients on potential for dizziness/drowsiness and caution with driving/machinery.
- Educate patients on taking with food to enhance absorption and reduce GI upset.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Tolperisone may cause dizziness or drowsiness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how they react to the medication.
Lifestyle Advice
- Avoid activities requiring mental alertness, such as driving or operating machinery, if you experience dizziness or drowsiness.
- Avoid alcohol consumption while on this medication as it may increase side effects.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.