Topicacin
Generic Name
Topicacin 0.025% w/w cream
Manufacturer
MediCare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| topicacin 0025 w cream | ৳ 50.00 | N/A |
Description
Overview of the medicine
Topicacin 0.025% w/w cream is a topical corticosteroid used to reduce inflammation, itching, and redness associated with various skin conditions.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected skin area once or twice daily, or as directed by the physician. Do not exceed 2 weeks of continuous use without re-evaluation.
Elderly
No specific dose adjustment required, but caution advised due to thinner skin.
Renal_impairment
No dose adjustment required for topical application.
How to Take
For external use only. Apply a thin film to the affected skin area and rub in gently. Wash hands immediately after use, unless hands are the treated area. Avoid contact with eyes, mouth, and mucous membranes.
Mechanism of Action
Topicacin exerts its anti-inflammatory, antipruritic, and vasoconstrictive effects by inducing phospholipase A2 inhibitory proteins, thereby controlling the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.
Pharmacokinetics
Onset
Within hours of application for symptomatic relief.
Excretion
Excreted via urine and bile if systemic absorption occurs.
Half life
Systemic half-life is variable but typically short; not clinically relevant for topical use unless extensive absorption occurs.
Absorption
Minimal systemic absorption, but can increase with prolonged use, large surface areas, and occlusive dressings. Intact skin absorbs approximately 1-5% of a topical dose.
Metabolism
Primarily metabolized in the skin and liver if absorbed systemically.
Side Effects
Contraindications
- Hypersensitivity to the active substance or any excipients
- Untreated cutaneous infections (viral, bacterial, fungal)
- Acne vulgaris, rosacea
- Perioral dermatitis
- Pruritus without inflammation
Drug Interactions
Systemic Corticosteroids
Increased risk of systemic side effects if Topicacin is absorbed significantly.
Other Topical Preparations
Avoid applying other topical products simultaneously to the same area unless advised by a doctor, as it may alter absorption or efficacy.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep away from direct heat.
Overdose
Acute overdose with topical corticosteroids is unlikely. Chronic overdose or misuse may lead to systemic effects such as Cushing's syndrome, hyperglycemia, or hypothalamic-pituitary-adrenal (HPA) axis suppression. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy or lactation only if the potential benefit justifies the potential risk to the fetus or infant. Consult a doctor. Avoid applying to large areas or for prolonged periods.
Side Effects
Contraindications
- Hypersensitivity to the active substance or any excipients
- Untreated cutaneous infections (viral, bacterial, fungal)
- Acne vulgaris, rosacea
- Perioral dermatitis
- Pruritus without inflammation
Drug Interactions
Systemic Corticosteroids
Increased risk of systemic side effects if Topicacin is absorbed significantly.
Other Topical Preparations
Avoid applying other topical products simultaneously to the same area unless advised by a doctor, as it may alter absorption or efficacy.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep away from direct heat.
Overdose
Acute overdose with topical corticosteroids is unlikely. Chronic overdose or misuse may lead to systemic effects such as Cushing's syndrome, hyperglycemia, or hypothalamic-pituitary-adrenal (HPA) axis suppression. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy or lactation only if the potential benefit justifies the potential risk to the fetus or infant. Consult a doctor. Avoid applying to large areas or for prolonged periods.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by Regulatory Authority (Hypothetical)
Patent Status
Generic available
Clinical Trials
Topical corticosteroids have undergone extensive clinical trials demonstrating efficacy in various inflammatory dermatoses. Specific trials for Topicacin (hypothetical) would focus on non-inferiority or superiority against existing moderate-potency corticosteroids.
Lab Monitoring
- Monitoring of HPA axis suppression may be considered in patients with extensive and/or prolonged use, especially in children, using tests like ACTH stimulation test or plasma cortisol levels.
Doctor Notes
- Educate patients on proper application technique and duration of therapy.
- Monitor for signs of skin atrophy, infection, or systemic absorption, especially in children or when applying to large surface areas.
- Consider a step-down approach or intermittent therapy for chronic conditions to minimize side effects.
Patient Guidelines
- Use as directed by your doctor. Do not use for longer than prescribed.
- Avoid applying to the face, groin, or armpits unless specifically instructed by a doctor.
- Do not cover the treated area with bandages or other occlusive dressings unless instructed by a doctor, as this can increase absorption and side effects.
- Keep out of reach of children.
Missed Dose Advice
If a dose is missed, apply it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not apply extra cream to make up for a missed dose.
Driving Precautions
Topicacin cream is for external use only and is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good skin hygiene and moisturize regularly to help manage underlying skin conditions.
- Avoid known irritants or allergens that may trigger your skin condition.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.