Topiderm
Generic Name
topiderm-2-1-cream
Manufacturer
Reputable Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| topiderm 2 1 cream | ৳ 145.00 | N/A |
Description
Overview of the medicine
Topiderm-2-1-cream is a topical preparation combining a potent corticosteroid (Betamethasone Valerate) and an antifungal agent (Miconazole Nitrate). It is used to treat various inflammatory skin conditions that are complicated by fungal infections, providing relief from itching, redness, and swelling while combating the fungal pathogen.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected area once or twice daily, as directed by a physician. Treatment duration should generally not exceed 2-4 weeks without re-evaluation.
Elderly
Same as adults, but caution should be exercised due to potential for thinner skin and increased systemic absorption.
Renal_impairment
No specific dosage adjustment required for topical application, as systemic absorption is minimal.
How to Take
For external use only. Apply thinly to the affected skin area and rub in gently. Wash hands before and after application. Avoid contact with eyes and mucous membranes.
Mechanism of Action
Betamethasone, a corticosteroid, acts by inhibiting the release of arachidonic acid metabolites, thereby reducing inflammation, itching, and vasoconstriction. Miconazole works by inhibiting the biosynthesis of ergosterol, an essential component of the fungal cell membrane, leading to increased cell membrane permeability and ultimate fungal cell death.
Pharmacokinetics
Onset
Relief of symptoms typically within a few days of starting treatment.
Excretion
Metabolites of Betamethasone are primarily excreted in urine. Miconazole metabolites are excreted via urine and feces.
Half life
Systemic half-life for absorbed Betamethasone is short, but topical effects persist. Miconazole's systemic half-life is around 24 hours, but topical effects are localized.
Absorption
Minimal systemic absorption through intact skin. Absorption increases with inflammation, skin barrier damage, or occlusive dressings. Miconazole has negligible systemic absorption.
Metabolism
Absorbed Betamethasone is metabolized in the liver. Miconazole is primarily metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Betamethasone, Miconazole, or any excipients
- Viral skin infections (e.g., herpes, varicella)
- Tuberculosis of the skin
- Acne vulgaris
- Rosacea
- Perioral dermatitis
- Ulcerated skin lesions
Drug Interactions
Other topical corticosteroids
Avoid concurrent use, as it may increase the risk of systemic absorption and side effects.
Warfarin (if systemic absorption occurs)
Increased anticoagulant effect possible due to Miconazole, requiring close monitoring.
Storage
Store below 30°C in a dry place, protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Acute topical overdose is unlikely to cause systemic effects. Chronic overuse, especially under occlusion or on large areas, may lead to systemic corticosteroid effects (e.g., Cushing's syndrome) or local skin atrophy. Discontinue use and manage symptomatically.
Pregnancy & Lactation
Use during pregnancy or lactation only if the potential benefit outweighs the potential risk to the fetus/infant, and under strict medical supervision. Avoid prolonged use or application to large areas.
Side Effects
Contraindications
- Hypersensitivity to Betamethasone, Miconazole, or any excipients
- Viral skin infections (e.g., herpes, varicella)
- Tuberculosis of the skin
- Acne vulgaris
- Rosacea
- Perioral dermatitis
- Ulcerated skin lesions
Drug Interactions
Other topical corticosteroids
Avoid concurrent use, as it may increase the risk of systemic absorption and side effects.
Warfarin (if systemic absorption occurs)
Increased anticoagulant effect possible due to Miconazole, requiring close monitoring.
Storage
Store below 30°C in a dry place, protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Acute topical overdose is unlikely to cause systemic effects. Chronic overuse, especially under occlusion or on large areas, may lead to systemic corticosteroid effects (e.g., Cushing's syndrome) or local skin atrophy. Discontinue use and manage symptomatically.
Pregnancy & Lactation
Use during pregnancy or lactation only if the potential benefit outweighs the potential risk to the fetus/infant, and under strict medical supervision. Avoid prolonged use or application to large areas.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Extensive clinical trials support the efficacy and safety of topical corticosteroids and antifungals in combination for indicated dermatological conditions, demonstrating significant reduction in inflammation and fungal load.
Lab Monitoring
- Generally not required for short-term topical use. For prolonged or extensive use, monitoring for adrenal suppression (e.g., plasma cortisol levels) may be considered.
Doctor Notes
- Emphasize short-term use for inflammatory skin conditions with fungal involvement.
- Educate patients on proper application technique and warning signs of local/systemic side effects.
- Avoid use on the face unless absolutely necessary and for very short periods due to risk of skin thinning.
- Consider re-evaluating diagnosis if no improvement after 7 days.
Patient Guidelines
- Use exactly as prescribed by your doctor.
- Do not cover the treated area with bandages or other dressings unless directed by your doctor.
- Avoid using on the face, groin, or armpits unless specifically instructed and for short durations.
- Report any worsening of symptoms or signs of infection to your doctor.
- Do not use for longer than the prescribed duration.
- Keep out of reach of children.
Missed Dose Advice
If a dose is missed, apply it as soon as remembered. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not apply a double dose.
Driving Precautions
Topical application is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good hygiene in the affected area.
- Wear loose-fitting clothing to avoid irritation.
- Avoid scratching the affected area to prevent further irritation or infection spread.
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