Topril
Generic Name
topril-50-mg-tablet
Manufacturer
Alpha Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| topril 50 mg tablet | ৳ 2.80 | ৳ 28.00 |
Description
Overview of the medicine
Topril 50 mg Tablet is an angiotensin-converting enzyme (ACE) inhibitor used to treat high blood pressure (hypertension), heart failure, and to reduce the risk of cardiovascular events in patients at high risk. It works by relaxing blood vessels, allowing blood to flow more easily.
Uses & Indications
Dosage
Adults
Hypertension: Initial dose 50 mg once daily. May be increased up to 100 mg once daily if needed. Heart failure: Initial dose 25 mg once daily, titrated up to 50-100 mg once daily as tolerated. Maximum daily dose 200 mg.
Elderly
Start with a lower dose (e.g., 25 mg once daily) and titrate carefully based on response and renal function.
Renal_impairment
Dosage adjustment is necessary. For creatinine clearance <30 mL/min, consider reducing the initial dose to 25 mg once daily and titrate cautiously. Close monitoring of renal function and potassium levels is essential.
How to Take
Topril 50 mg Tablet should be taken orally once daily, with or without food. It is recommended to take it at approximately the same time each day.
Mechanism of Action
Topril inhibits the angiotensin-converting enzyme (ACE), which is responsible for converting angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor and stimulates aldosterone secretion. By inhibiting ACE, Topril reduces angiotensin II levels, leading to vasodilation, decreased aldosterone secretion, reduced sodium and water reabsorption, and consequently, a reduction in blood pressure and cardiac workload.
Pharmacokinetics
Onset
Onset of action within 1-2 hours, peak effect within 3-6 hours.
Excretion
Excreted mainly via the kidneys, both as active metabolite and inactive compounds.
Half life
Approximately 8-12 hours for the active metabolite.
Absorption
Rapidly absorbed after oral administration. Bioavailability may vary.
Metabolism
Primarily metabolized in the liver to its active metabolite and inactive compounds.
Side Effects
Contraindications
- Hypersensitivity to topril or any other ACE inhibitor
- History of angioedema related to previous ACE inhibitor treatment
- Hereditary or idiopathic angioedema
- Second and third trimesters of pregnancy
- Bilateral renal artery stenosis
Drug Interactions
NSAIDs
May reduce the antihypertensive effect of Topril and increase the risk of renal impairment.
Lithium
Increased serum lithium levels and lithium toxicity. Monitor lithium levels carefully.
Diuretics
Increased hypotensive effect. Monitor blood pressure closely.
Potassium-sparing diuretics/Potassium supplements
Increased risk of hyperkalemia. Avoid concomitant use or monitor potassium levels frequently.
Dual blockade of the RAAS (e.g., with ARBs or Aliskiren)
Increased risk of hypotension, hyperkalemia, and renal impairment. Not recommended.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe hypotension, shock, bradycardia, electrolyte disturbances, and renal failure. Treatment involves symptomatic and supportive measures, including intravenous fluid administration for hypotension and hemodialysis if necessary.
Pregnancy & Lactation
Topril is contraindicated during the second and third trimesters of pregnancy due to risks of fetal injury and death. Discontinue immediately if pregnancy is detected. It is not recommended during breastfeeding as it may pass into breast milk and harm the infant.
Side Effects
Contraindications
- Hypersensitivity to topril or any other ACE inhibitor
- History of angioedema related to previous ACE inhibitor treatment
- Hereditary or idiopathic angioedema
- Second and third trimesters of pregnancy
- Bilateral renal artery stenosis
Drug Interactions
NSAIDs
May reduce the antihypertensive effect of Topril and increase the risk of renal impairment.
Lithium
Increased serum lithium levels and lithium toxicity. Monitor lithium levels carefully.
Diuretics
Increased hypotensive effect. Monitor blood pressure closely.
Potassium-sparing diuretics/Potassium supplements
Increased risk of hyperkalemia. Avoid concomitant use or monitor potassium levels frequently.
Dual blockade of the RAAS (e.g., with ARBs or Aliskiren)
Increased risk of hypotension, hyperkalemia, and renal impairment. Not recommended.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe hypotension, shock, bradycardia, electrolyte disturbances, and renal failure. Treatment involves symptomatic and supportive measures, including intravenous fluid administration for hypotension and hemodialysis if necessary.
Pregnancy & Lactation
Topril is contraindicated during the second and third trimesters of pregnancy due to risks of fetal injury and death. Discontinue immediately if pregnancy is detected. It is not recommended during breastfeeding as it may pass into breast milk and harm the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Available in pharmacies, hospitals, and clinics
Approval Status
Approved by national health authorities
Patent Status
Generic versions available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of ACE inhibitors like Topril in reducing blood pressure and improving cardiovascular outcomes. Specific trials for 'topril' would confirm its profile, often compared against placebo or other antihypertensives.
Lab Monitoring
- Blood pressure monitoring (regularly)
- Serum creatinine and BUN (before treatment and periodically during treatment)
- Serum potassium (before treatment and periodically during treatment)
- Complete blood count (periodically, especially in patients with renal impairment or collagen vascular disease)
Doctor Notes
- Emphasize patient education on compliance and importance of regular blood pressure and laboratory monitoring.
- Counsel patients on potential side effects, especially angioedema and persistent cough, and when to seek immediate medical attention.
- Careful titration is required, particularly in elderly patients or those with renal impairment.
Patient Guidelines
- Take Topril exactly as prescribed by your doctor.
- Do not stop taking the medicine without consulting your doctor, even if you feel better.
- Report any persistent dry cough, swelling of the face, lips, tongue, or throat immediately.
- Avoid potassium supplements or salt substitutes containing potassium unless advised by your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Topril may cause dizziness or lightheadedness, especially after the first dose or when the dose is increased. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Adopt a low-sodium diet and limit processed foods.
- Engage in regular physical activity as advised by your doctor.
- Maintain a healthy weight and avoid smoking.
- Limit alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.