Torax
Generic Name
Torasemide
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| torax 10 mg tablet | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Torax 10 mg Tablet contains Torasemide, a loop diuretic used to treat edema associated with congestive heart failure, renal disease, and hepatic cirrhosis. It is also used for the treatment of hypertension.
Uses & Indications
Dosage
Adults
For edema: Usually 5-20 mg once daily. For hypertension: Usually 2.5-5 mg once daily. The dose can be adjusted based on clinical response.
Elderly
Similar to adult dosage, but titration should be done carefully due to potential for decreased renal function.
Renal_impairment
No specific dose adjustment is required for mild to moderate renal impairment, but caution is advised. For severe renal impairment, lower doses or extended intervals may be necessary.
How to Take
Oral administration. Can be taken with or without food, usually in the morning to avoid nocturnal diuresis.
Mechanism of Action
Torasemide acts on the thick ascending limb of the loop of Henle in the kidney to inhibit the Na+/K+/2Cl- cotransporter, leading to increased excretion of sodium, chloride, and water.
Pharmacokinetics
Onset
Diuretic effect begins within 1 hour after oral administration.
Excretion
Mainly excreted by the kidneys (approximately 80% as metabolites and 20% as unchanged drug).
Half life
Approximately 3.5 hours in healthy individuals; may be prolonged in renal or hepatic impairment.
Absorption
Rapidly and almost completely absorbed after oral administration. Bioavailability is approximately 80-90%. Peak plasma concentrations are achieved within 1 hour.
Metabolism
Metabolized in the liver by cytochrome P450 enzymes, primarily CYP2C9, to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to torasemide or sulfonylureas
- Anuria
- Hepatic coma or pre-coma
- Hypotension
- Severe electrolyte depletion
Drug Interactions
Digoxin
Increased risk of digoxin toxicity due to hypokalemia.
Lithium
Reduced renal clearance of lithium, leading to increased lithium levels and toxicity.
Corticosteroids
Increased risk of hypokalemia.
Aminoglycoside antibiotics
Increased risk of ototoxicity and nephrotoxicity.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce diuretic and antihypertensive effects of torasemide.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include profound diuresis, electrolyte depletion (hypokalemia, hyponatremia), hypotension, and dehydration. Management involves fluid and electrolyte replacement and symptomatic support.
Pregnancy & Lactation
Should only be used if the potential benefit justifies the potential risk to the fetus/infant. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to torasemide or sulfonylureas
- Anuria
- Hepatic coma or pre-coma
- Hypotension
- Severe electrolyte depletion
Drug Interactions
Digoxin
Increased risk of digoxin toxicity due to hypokalemia.
Lithium
Reduced renal clearance of lithium, leading to increased lithium levels and toxicity.
Corticosteroids
Increased risk of hypokalemia.
Aminoglycoside antibiotics
Increased risk of ototoxicity and nephrotoxicity.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce diuretic and antihypertensive effects of torasemide.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include profound diuresis, electrolyte depletion (hypokalemia, hyponatremia), hypotension, and dehydration. Management involves fluid and electrolyte replacement and symptomatic support.
Pregnancy & Lactation
Should only be used if the potential benefit justifies the potential risk to the fetus/infant. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory bodies
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of torasemide in the treatment of edema and hypertension.
Lab Monitoring
- Serum electrolytes (especially potassium)
- Renal function (BUN, creatinine)
- Blood pressure
- Fluid balance
Doctor Notes
- Monitor electrolyte levels regularly, especially potassium.
- Advise patients on symptoms of dehydration and electrolyte imbalance.
- Adjust dose based on patient's response and renal function.
- Avoid concomitant use with nephrotoxic or ototoxic drugs if possible.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking the medicine without consulting your doctor.
- Report any unusual side effects to your doctor.
- Maintain adequate fluid intake unless advised otherwise.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose.
Driving Precautions
May cause dizziness or lightheadedness, especially at the start of treatment. Exercise caution when driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet.
- Limit sodium intake.
- Engage in regular physical activity as advised by your doctor.
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