Torosic
Generic Name
Torsemide
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| torosic 10 mg tablet | ৳ 12.00 | ৳ 168.00 |
Description
Overview of the medicine
Torosic 10 mg Tablet contains Torsemide, a loop diuretic used to treat fluid retention (edema) associated with heart failure, kidney disease, or liver disease, and high blood pressure.
Uses & Indications
Dosage
Adults
Edema: Initially 5-20 mg once daily, adjusted based on response up to 200 mg daily. Hypertension: Initially 2.5-5 mg once daily, adjusted based on response up to 10 mg daily.
Elderly
No specific dose adjustment generally required, but close monitoring is advised due to increased risk of electrolyte imbalance.
Renal_impairment
Dose adjustment may be necessary in severe renal failure. Max 200 mg daily.
How to Take
Take orally, with or without food, usually once daily in the morning.
Mechanism of Action
Torsemide acts on the thick ascending limb of the loop of Henle in the kidneys, inhibiting the sodium-potassium-chloride cotransporter (NKCC2). This prevents the reabsorption of sodium, chloride, and water, leading to increased urine output.
Pharmacokinetics
Onset
Within 1 hour (oral).
Excretion
Primarily excreted via the kidneys (approx. 80% as metabolites, 20% unchanged drug).
Half life
Approximately 3.5 hours. Can be prolonged in hepatic or renal impairment.
Absorption
Rapidly and almost completely absorbed from the GI tract. Bioavailability is ~80-90%. Peak plasma concentrations achieved within 1 hour.
Metabolism
Primarily metabolized in the liver by cytochrome P450 2C9 (CYP2C9) to inactive and weakly active metabolites.
Side Effects
Contraindications
- Anuria (absence of urine production)
- Hypersensitivity to torsemide or sulfonylureas
- Hepatic coma and pre-coma states
Drug Interactions
NSAIDs
May reduce diuretic and antihypertensive effects of torsemide.
Digoxin
May increase the risk of digoxin toxicity due to electrolyte imbalance (hypokalemia).
Lithium
May reduce renal clearance of lithium, leading to increased lithium levels and toxicity.
Aminoglycosides/Ethacrynic acid
Increased risk of ototoxicity.
Storage
Store below 30°C, in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include dehydration, electrolyte depletion (hypokalemia, hyponatremia), hypotension. Management involves symptomatic and supportive care, fluid and electrolyte replacement.
Pregnancy & Lactation
Pregnancy Category B (animal studies show no risk, but human data limited). Use only if clearly needed. Excreted in breast milk, use with caution or consider alternatives.
Side Effects
Contraindications
- Anuria (absence of urine production)
- Hypersensitivity to torsemide or sulfonylureas
- Hepatic coma and pre-coma states
Drug Interactions
NSAIDs
May reduce diuretic and antihypertensive effects of torsemide.
Digoxin
May increase the risk of digoxin toxicity due to electrolyte imbalance (hypokalemia).
Lithium
May reduce renal clearance of lithium, leading to increased lithium levels and toxicity.
Aminoglycosides/Ethacrynic acid
Increased risk of ototoxicity.
Storage
Store below 30°C, in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include dehydration, electrolyte depletion (hypokalemia, hyponatremia), hypotension. Management involves symptomatic and supportive care, fluid and electrolyte replacement.
Pregnancy & Lactation
Pregnancy Category B (animal studies show no risk, but human data limited). Use only if clearly needed. Excreted in breast milk, use with caution or consider alternatives.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated its efficacy in treating edema and hypertension.
Lab Monitoring
- Serum electrolytes (potassium, sodium, magnesium, calcium)
- Renal function (BUN, creatinine)
- Liver function tests
Doctor Notes
- Monitor electrolyte levels regularly, especially potassium and sodium.
- Educate patients on signs of dehydration and hypokalemia.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Report any signs of dehydration or electrolyte imbalance (e.g., muscle cramps, weakness) to your doctor.
- Avoid excessive sun exposure as diuretics can increase photosensitivity.
Missed Dose Advice
Take the missed dose as soon as you remember. If it's almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness. Exercise caution when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain adequate fluid intake unless otherwise advised by your doctor.
- Follow a low-sodium diet to enhance the effect of the medicine.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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