Torva
Generic Name
Atorvastatin 10 mg tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| torva 10 mg tablet | ৳ 10.00 | N/A |
Description
Overview of the medicine
Atorvastatin 10 mg tablet is used to lower high cholesterol and triglyceride levels in the blood, thereby reducing the risk of heart disease, stroke, and other cardiovascular events. It works by inhibiting an enzyme in the liver responsible for cholesterol production.
Uses & Indications
Dosage
Adults
Initial dose 10-20 mg once daily. Dosage can be adjusted based on lipid levels and therapeutic goals, typically ranging from 10 to 80 mg once daily.
Elderly
No specific dosage adjustment is required. However, use with caution and monitor for adverse effects.
Renal_impairment
No dosage adjustment is necessary for patients with renal impairment.
How to Take
Torva 10 mg tablet should be taken orally once daily, with or without food, at any time of day. It is recommended to take it at the same time each day to maintain consistent drug levels.
Mechanism of Action
Atorvastatin selectively inhibits HMG-CoA reductase, an enzyme that catalyzes the conversion of HMG-CoA to mevalonate, which is a key step in cholesterol biosynthesis. This inhibition leads to a decrease in hepatic cholesterol synthesis and an increase in the number of LDL receptors on the hepatocyte surface, enhancing LDL catabolism.
Pharmacokinetics
Onset
Lipid-lowering effects begin within 2 weeks of treatment, with maximal responses observed within 4 weeks.
Excretion
Primarily eliminated via biliary excretion following hepatic and/or extrahepatic metabolism. Less than 2% of a dose is recovered in the urine.
Half life
The apparent elimination half-life of atorvastatin and its active metabolites is approximately 14 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations occurring within 1-2 hours. Absolute bioavailability is approximately 12-14% due to extensive first-pass metabolism.
Metabolism
Extensively metabolized in the liver, primarily by cytochrome P450 3A4 (CYP3A4) to ortho- and parahydroxylated derivatives and various beta-oxidation products. These metabolites are active and contribute to the pharmacological effect.
Side Effects
Contraindications
- Active liver disease or unexplained persistent elevations of serum transaminases.
- Pregnancy and lactation.
- Hypersensitivity to atorvastatin or any component of the tablet.
Drug Interactions
Warfarin
Enhanced anticoagulant effect; monitor INR closely.
Cyclosporine, gemfibrozil, niacin
Increased risk of myopathy/rhabdomyolysis when co-administered with atorvastatin.
CYP3A4 inhibitors (e.g., clarithromycin, itraconazole, protease inhibitors)
Increased plasma concentrations of atorvastatin, leading to an increased risk of myopathy.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
There is no specific antidote for atorvastatin overdose. In case of an overdose, symptomatic and supportive measures should be initiated. Liver function tests and CK levels should be monitored.
Pregnancy & Lactation
Atorvastatin is contraindicated during pregnancy and breastfeeding. Women of childbearing potential should use effective contraception during treatment. If pregnancy occurs, atorvastatin should be discontinued immediately.
Side Effects
Contraindications
- Active liver disease or unexplained persistent elevations of serum transaminases.
- Pregnancy and lactation.
- Hypersensitivity to atorvastatin or any component of the tablet.
Drug Interactions
Warfarin
Enhanced anticoagulant effect; monitor INR closely.
Cyclosporine, gemfibrozil, niacin
Increased risk of myopathy/rhabdomyolysis when co-administered with atorvastatin.
CYP3A4 inhibitors (e.g., clarithromycin, itraconazole, protease inhibitors)
Increased plasma concentrations of atorvastatin, leading to an increased risk of myopathy.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
There is no specific antidote for atorvastatin overdose. In case of an overdose, symptomatic and supportive measures should be initiated. Liver function tests and CK levels should be monitored.
Pregnancy & Lactation
Atorvastatin is contraindicated during pregnancy and breastfeeding. Women of childbearing potential should use effective contraception during treatment. If pregnancy occurs, atorvastatin should be discontinued immediately.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Generally 2 to 3 years from the date of manufacture, depending on the manufacturer.
Availability
Available in pharmacies and hospitals
Approval Status
Approved (e.g., FDA/DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Numerous large-scale randomized controlled clinical trials, such as ASCOT-LLA, TNT, IDEAL, and MIRACL, have demonstrated the efficacy of atorvastatin in reducing major cardiovascular events (e.g., nonfatal myocardial infarction, fatal coronary heart disease, stroke) across a broad range of patient populations.
Lab Monitoring
- Liver function tests (ALT/AST) should be performed before initiating treatment and periodically thereafter (e.g., at 6 and 12 weeks after initiation or dose escalation, then annually).
- Lipid panel (total cholesterol, LDL-C, HDL-C, triglycerides) to monitor therapeutic efficacy and guide dose adjustments.
Doctor Notes
- Emphasize the importance of consistent adherence to medication and lifestyle modifications (diet, exercise) for optimal lipid management and cardiovascular risk reduction.
- Educate patients about muscle-related side effects and advise them to report any unexplained muscle pain, tenderness, or weakness promptly.
- Monitor liver function tests (ALT/AST) and creatine kinase (CK) levels at baseline and periodically during treatment, especially when increasing the dose or co-administering with interacting drugs.
Patient Guidelines
- Take Torva exactly as prescribed by your doctor, preferably at the same time each day.
- Do not stop taking the medicine without consulting your doctor, even if you feel well.
- Report any unexplained muscle pain, tenderness, or weakness, especially if accompanied by fever or malaise, to your doctor immediately.
- Follow the prescribed diet and exercise regimen along with the medication for best results.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Atorvastatin generally does not affect the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, you should avoid such activities.
Lifestyle Advice
- Adopt a healthy diet low in saturated and trans fats, and rich in fruits, vegetables, and whole grains.
- Engage in regular physical activity for at least 30 minutes most days of the week.
- Quit smoking and limit alcohol consumption to help manage cholesterol levels and reduce cardiovascular risk.
- Maintain a healthy weight.
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