Torvas
Generic Name
Atorvastatin Calcium
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| torvas 10 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Atorvastatin is an HMG-CoA reductase inhibitor (statin) used to lower cholesterol and triglycerides in the blood and reduce the risk of cardiovascular diseases.
Uses & Indications
Dosage
Adults
Initial 10-20 mg once daily, adjusted to 10-80 mg once daily based on response.
Elderly
No specific dosage adjustment required.
Renal_impairment
No dosage adjustment required for patients with renal impairment.
How to Take
Take orally once daily, with or without food, at any time of day.
Mechanism of Action
Atorvastatin selectively inhibits HMG-CoA reductase, the rate-limiting enzyme that catalyzes the conversion of 3-hydroxy-3-methylglutaryl-coenzyme A to mevalonate, a precursor of sterols, including cholesterol.
Pharmacokinetics
Onset
Lipid-lowering effects seen within 2 weeks, maximal at 4 weeks.
Excretion
Primarily excreted in bile following hepatic and/or extrahepatic metabolism.
Half life
Parent drug: approximately 14 hours; active metabolites: 20-30 hours.
Absorption
Rapidly absorbed; Tmax 1-2 hours; absolute bioavailability approximately 12%.
Metabolism
Extensively metabolized by CYP3A4 to ortho- and parahydroxylated derivatives and various beta-oxidation products.
Side Effects
Contraindications
- Active liver disease or unexplained persistent elevations of serum transaminases
- Pregnancy
- Lactation
- Hypersensitivity to any component of this medication
Drug Interactions
Niacin
Increased risk of muscle side effects.
Colchicine
Cases of myopathy/rhabdomyolysis reported with coadministration.
Cyclosporine
Significantly increased atorvastatin exposure; avoid combination.
Gemfibrozil and other fibrates
Increased risk of myopathy/rhabdomyolysis.
Strong CYP3A4 Inhibitors (e.g., Itraconazole, Clarithromycin)
Increased plasma concentrations of atorvastatin, increasing risk of myopathy.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. In the event of overdose, the patient should be treated symptomatically and supportive measures instituted as required.
Pregnancy & Lactation
Contraindicated in pregnancy and lactation due to potential for fetal harm and excretion into breast milk.
Side Effects
Contraindications
- Active liver disease or unexplained persistent elevations of serum transaminases
- Pregnancy
- Lactation
- Hypersensitivity to any component of this medication
Drug Interactions
Niacin
Increased risk of muscle side effects.
Colchicine
Cases of myopathy/rhabdomyolysis reported with coadministration.
Cyclosporine
Significantly increased atorvastatin exposure; avoid combination.
Gemfibrozil and other fibrates
Increased risk of myopathy/rhabdomyolysis.
Strong CYP3A4 Inhibitors (e.g., Itraconazole, Clarithromycin)
Increased plasma concentrations of atorvastatin, increasing risk of myopathy.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. In the event of overdose, the patient should be treated symptomatically and supportive measures instituted as required.
Pregnancy & Lactation
Contraindicated in pregnancy and lactation due to potential for fetal harm and excretion into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years
Availability
Available in pharmacies and hospitals
Approval Status
Approved by FDA/DGDA
Patent Status
Patent expired for generic, brand patents vary
Clinical Trials
Extensively studied in numerous clinical trials, including ASCOT-LLA, REVERSAL, and TNT trials, demonstrating efficacy in reducing cardiovascular events.
Lab Monitoring
- Liver function tests (LFTs) before initiation and periodically thereafter
- Lipid panel (total cholesterol, LDL-C, HDL-C, triglycerides)
Doctor Notes
- Emphasize the importance of lifestyle modifications (diet, exercise) along with medication.
- Regularly monitor liver function tests (LFTs) and lipid profiles.
- Advise patients to report any muscle pain, tenderness, or weakness promptly.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Report any unexplained muscle pain, tenderness, or weakness to your doctor immediately.
- Avoid consuming large amounts of grapefruit juice while on this medication.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Atorvastatin has negligible or no influence on the ability to drive and use machines. However, if dizziness occurs, patients should be cautious.
Lifestyle Advice
- Maintain a healthy diet low in saturated and trans fats.
- Engage in regular physical activity.
- Quit smoking and reduce alcohol consumption.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Torvas Brand
Other medicines available under the same brand name
