Toti
Generic Name
Toti 1 mg Tablet
Manufacturer
Medi Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| toti 1 mg tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Toti 1 mg Tablet is an anxiolytic medication used to treat generalized anxiety disorder and short-term insomnia. It works by enhancing the effect of a natural chemical in the body (GABA) that calms brain activity.
Uses & Indications
Dosage
Adults
Initial dose 0.5 mg - 1 mg once daily, preferably at bedtime. Max 2 mg/day, adjusted based on response and tolerability.
Elderly
Initial dose 0.5 mg once daily, preferably at bedtime. Dose adjustments should be made cautiously due to increased sensitivity.
Renal_impairment
Use with caution. Dosage adjustments may be necessary, starting with a lower dose (e.g., 0.5 mg once daily).
How to Take
Take the tablet orally with a glass of water, with or without food. Do not crush, chew, or break the tablet.
Mechanism of Action
Toti acts by potentiating the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in the central nervous system, leading to calming effects and reduced anxiety.
Pharmacokinetics
Onset
Anxiolytic and sedative effects typically begin within 30-60 minutes.
Excretion
Mainly excreted in the urine as glucuronide conjugates.
Half life
Approximately 6-8 hours, with some inter-individual variability.
Absorption
Rapidly and well absorbed after oral administration, with peak plasma concentrations reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver via glucuronidation. No significant active metabolites.
Side Effects
Contraindications
- Hypersensitivity to Toti or any excipients
- Severe respiratory depression
- Acute narrow-angle glaucoma
- Myasthenia gravis
- Severe hepatic insufficiency
- Sleep apnea syndrome
Drug Interactions
Anticonvulsants
Additive CNS depression; monitor for excessive sedation.
CYP3A4 Inhibitors (e.g., ketoconazole, erythromycin)
May increase Toti plasma concentrations, leading to enhanced effects.
CNS Depressants (e.g., alcohol, opioids, other anxiolytics)
Increased risk of sedation, respiratory depression, and hypotension.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe drowsiness, confusion, slowed reflexes, slurred speech, hypotension, and respiratory depression. Management includes supportive care, maintaining airway, gastric lavage (if recent ingestion), and administration of flumazenil (if appropriate and carefully considered for benzodiazepine-like action).
Pregnancy & Lactation
Not recommended during pregnancy due to potential risks of congenital malformations and neonatal withdrawal symptoms. Excreted in breast milk; therefore, not recommended during lactation. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
DGDA Approved (Bangladesh)
Patent Status
Patented
Clinical Trials
Clinical trials have demonstrated efficacy in reducing anxiety symptoms and improving sleep in adult patients. Phase III trials confirmed safety and tolerability profile. Post-marketing surveillance is ongoing.
Lab Monitoring
- Liver function tests (baseline and periodically during long-term therapy)
- Renal function tests (for patients with renal impairment)
Doctor Notes
- Careful assessment of patient's history of substance abuse is crucial before prescribing.
- Initiate at the lowest effective dose and gradually titrate if needed. Avoid abrupt discontinuation; taper dose slowly.
- Monitor for signs of respiratory depression, especially with concomitant use of other CNS depressants.
- Educate patients about the risks of dependence and withdrawal.
Patient Guidelines
- Do not suddenly stop taking Toti without consulting your doctor, as this may lead to withdrawal symptoms.
- Avoid alcohol consumption while taking this medicine as it can increase drowsiness.
- Do not drive or operate heavy machinery until you know how Toti affects you.
- Report any unusual mood changes or severe side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Toti may cause drowsiness, dizziness, or blurred vision. Patients should be advised not to drive or operate hazardous machinery until they are certain that Toti does not adversely affect their ability to perform such activities.
Lifestyle Advice
- Practice stress-reducing techniques such as meditation or yoga.
- Maintain a regular sleep schedule to improve sleep hygiene.
- Limit caffeine and nicotine intake, especially in the evening.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.