Toujeo SoloStar
Generic Name
Insulin Glargine (rDNA origin)
Manufacturer
Sanofi
Country
France / Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| toujeo solostar 300 iu injection | ৳ 2,305.00 | N/A |
Description
Overview of the medicine
Toujeo SoloStar 300 IU/mL is a long-acting insulin glargine formulation used to improve glycemic control in adults and pediatric patients 6 years and older with diabetes mellitus. It provides a stable, long-lasting glucose-lowering effect over 24 hours with a lower risk of nocturnal hypoglycemia compared to U-100 insulin glargine.
Uses & Indications
Dosage
Adults
Individualized, usually once daily at the same time each day. For Type 1, initial dose is approx. one-third of total daily insulin dose. For Type 2, initial dose is 0.2 units/kg once daily, then adjusted based on glucose levels.
Elderly
No specific dose adjustment needed, but careful monitoring is recommended due to potential for renal impairment and increased risk of hypoglycemia.
Renal_impairment
Dose adjustment may be required; careful monitoring of glucose is essential. Avoid abrupt changes.
How to Take
Administer subcutaneously once daily at the same time each day. Rotate injection sites within the same region (e.g., abdomen, thigh, deltoid) to reduce the risk of lipodystrophy. Do not administer intravenously or intramuscularly. Do not dilute or mix with other insulins.
Mechanism of Action
Insulin glargine is a recombinant human insulin analogue that lowers blood glucose by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulin also inhibits lipolysis and proteolysis, and enhances protein synthesis.
Pharmacokinetics
Onset
Approximately 6 hours.
Excretion
Primarily via urine as metabolites.
Half life
Not directly applicable due to its complex release mechanism; effective duration of action is >24 hours.
Absorption
Slow and prolonged absorption from the subcutaneous injection site due to formation of microprecipitates. Peakless profile with stable plasma concentrations.
Metabolism
Partially metabolized at the injection site, primarily metabolized in the liver to two active metabolites (M1 and M2).
Side Effects
Contraindications
- •During episodes of hypoglycemia
- •Patients with hypersensitivity to insulin glargine or any excipients in the formulation
Drug Interactions
Drugs that may decrease hypoglycemic effect (reduced insulin effect)
Atypical antipsychotics (e.g., olanzapine, clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens, protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), thyroid hormones.
Drugs that may increase hypoglycemic effect (increased risk of hypoglycemia)
Oral antidiabetic agents, ACE inhibitors, angiotensin II receptor blockers, disopyramide, fibrates, fluoxetine, MAO inhibitors, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs (e.g., octreotide), sulfa antibiotics, alcohol.
Storage
Unopened: Store in a refrigerator (2°C-8°C). Do not freeze. Protect from light. Opened (in-use): Store at room temperature (below 30°C) or in a refrigerator (2°C-8°C) for up to 42 days. Do not freeze. Keep the pen cap on to protect from light.
Overdose
Overdose can lead to severe and prolonged hypoglycemia, which may be life-threatening. Mild hypoglycemia can be treated with oral glucose or carbohydrate. Severe hypoglycemia may require glucagon injection or intravenous glucose. Close monitoring is essential.
Pregnancy & Lactation
Limited data on Toujeo in pregnancy; use only if potential benefit justifies potential risk to the fetus. Insulin does not cross the placenta. Caution when administered to a nursing mother; insulin is excreted in breast milk but is unlikely to cause adverse effects in the infant due to degradation in the gastrointestinal tract.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Unopened: 3 years from manufacture date when stored refrigerated (2°C-8°C). Opened: 42 days when stored at room temperature (below 30°C) or refrigerated (2°C-8°C).
Availability
Pharmacies, Hospitals
Approval Status
FDA Approved (2015)
Patent Status
Patent protected
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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