Trado Plus
Generic Name
Tramadol Hydrochloride + Paracetamol
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| trado plus 325 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Trado Plus is a combination medicine containing Tramadol and Paracetamol, used to relieve moderate to moderately severe pain.
Uses & Indications
Dosage
Adults
Initial dose of 1-2 tablets every 4-6 hours as needed, not exceeding 8 tablets in 24 hours.
Elderly
Similar to adults, but dosage adjustment may be needed based on renal/hepatic function. Maximum 8 tablets per 24 hours.
Renal_impairment
Dose interval may need to be extended (e.g., 12 hours) in patients with severe renal impairment (CrCl < 30 mL/min). Maximum 2 tablets per 24 hours.
How to Take
Take orally with or without food. Do not crush or chew the tablet.
Mechanism of Action
Tramadol acts centrally as an opioid agonist and inhibits norepinephrine and serotonin reuptake. Paracetamol acts primarily in the central nervous system to inhibit prostaglandin synthesis.
Pharmacokinetics
Onset
Analgesic effect typically begins within 30-60 minutes.
Excretion
Primarily excreted renally as metabolites.
Half life
Tramadol: approx. 5-7 hours; Paracetamol: approx. 2-3 hours.
Absorption
Tramadol and paracetamol are rapidly and well absorbed after oral administration.
Metabolism
Both are extensively metabolized in the liver (Tramadol via CYP2D6 and CYP3A4, Paracetamol via glucuronidation and sulfation).
Side Effects
Contraindications
- Hypersensitivity to tramadol, paracetamol, or any component
- Acute intoxication with alcohol, hypnotics, opioids, centrally acting analgesics, psychotropic drugs
- Severe respiratory depression
- Severe hepatic impairment
- Epilepsy not controlled by treatment
Drug Interactions
Carbamazepine
Significantly reduces tramadol plasma concentrations.
MAO inhibitors
Increased risk of serotonin syndrome and seizures.
Warfarin and coumarin derivatives
Increased INR, leading to bleeding risk.
Serotonergic drugs (e.g., SSRIs, TCAs)
Increased risk of serotonin syndrome.
CNS depressants (e.g., alcohol, benzodiazepines)
Increased risk of respiratory depression, sedation, coma, and death.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include respiratory depression, seizures, coma, hepatic necrosis (paracetamol component). Treatment involves supportive care, naloxone for opioid effects, and N-acetylcysteine for paracetamol toxicity.
Pregnancy & Lactation
Not recommended during pregnancy (risk of neonatal opioid withdrawal syndrome). Use with caution during lactation; small amounts of tramadol and paracetamol pass into breast milk.
Side Effects
Contraindications
- Hypersensitivity to tramadol, paracetamol, or any component
- Acute intoxication with alcohol, hypnotics, opioids, centrally acting analgesics, psychotropic drugs
- Severe respiratory depression
- Severe hepatic impairment
- Epilepsy not controlled by treatment
Drug Interactions
Carbamazepine
Significantly reduces tramadol plasma concentrations.
MAO inhibitors
Increased risk of serotonin syndrome and seizures.
Warfarin and coumarin derivatives
Increased INR, leading to bleeding risk.
Serotonergic drugs (e.g., SSRIs, TCAs)
Increased risk of serotonin syndrome.
CNS depressants (e.g., alcohol, benzodiazepines)
Increased risk of respiratory depression, sedation, coma, and death.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include respiratory depression, seizures, coma, hepatic necrosis (paracetamol component). Treatment involves supportive care, naloxone for opioid effects, and N-acetylcysteine for paracetamol toxicity.
Pregnancy & Lactation
Not recommended during pregnancy (risk of neonatal opioid withdrawal syndrome). Use with caution during lactation; small amounts of tramadol and paracetamol pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA, Bangladesh
Patent Status
Off-patent (generic available)
Clinical Trials
Numerous clinical trials have established the efficacy and safety of tramadol/paracetamol combination for moderate to severe pain.
Lab Monitoring
- Liver function tests (especially with prolonged use)
- Renal function tests
- INR (if on warfarin)
Doctor Notes
- Assess patient's pain level and history of substance abuse before prescribing.
- Educate patients on potential for dependence and proper disposal.
- Monitor for signs of respiratory depression, especially with concomitant CNS depressants.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid alcohol while taking this medicine.
- Inform your doctor about all other medications you are taking.
- Do not stop suddenly if used long-term; consult your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness; do not drive or operate heavy machinery if affected.
Lifestyle Advice
- Avoid activities requiring mental alertness (e.g., driving) if experiencing dizziness or drowsiness.
- Stay hydrated.
- Maintain a balanced diet to manage constipation.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.