trapic
Generic Name
Tranexamic Acid
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| trapic 500 mg tablet | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Trapic 500 mg Tablet contains Tranexamic Acid, which is an antifibrinolytic agent used to prevent or reduce excessive bleeding in various conditions such as heavy menstrual bleeding, nosebleeds, and bleeding after surgery or trauma.
Uses & Indications
Dosage
Adults
For menorrhagia: 1-1.5 g (2-3 tablets of 500 mg) 3-4 times daily for 3-5 days. For other indications, dose varies, typically 1 g 2-3 times daily or as prescribed by a physician.
Elderly
No specific dose adjustment is required unless there is renal impairment. Start with lower doses and monitor renal function.
Renal_impairment
Dosage must be reduced according to creatinine clearance. E.g., CrCl 30-59 mL/min: 500 mg twice daily. CrCl 10-29 mL/min: 500 mg once daily. CrCl <10 mL/min: 250 mg once daily.
How to Take
Take the tablet orally with water, with or without food. Follow the duration of treatment as advised by your doctor.
Mechanism of Action
Tranexamic acid inhibits fibrinolysis by competitively blocking plasminogen binding sites on fibrin, preventing the activation of plasminogen to plasmin. Plasmin is an enzyme that breaks down fibrin blood clots. By inhibiting plasmin, tranexamic acid helps to stabilize blood clots and reduce bleeding.
Pharmacokinetics
Onset
Antifibrinolytic effect within 30 minutes after intravenous administration; longer for oral.
Excretion
Excreted primarily unchanged in the urine via glomerular filtration. 90% of the dose is excreted within 24 hours.
Half life
Approximately 2-11 hours (dependent on dose and renal function).
Absorption
Well absorbed from the gastrointestinal tract. Peak plasma concentration achieved within 3 hours after oral administration.
Metabolism
Minimally metabolized; less than 5% is metabolized.
Side Effects
Contraindications
- Hypersensitivity to tranexamic acid or any component of the formulation
- Active intravascular clotting
- Severe renal impairment (risk of accumulation)
- History of convulsions
- Subarachnoid hemorrhage (risk of cerebral edema and infarction)
- Concomitant use of hormonal contraceptives (increased risk of thrombosis)
Drug Interactions
Urokinase
Reduced efficacy.
Combined hormonal contraceptives
Increased risk of thrombosis (blood clots). Avoid concomitant use.
Thrombolytic agents (e.g., Alteplase, Streptokinase)
Antagonistic effect; reduces efficacy of thrombolytics.
Factor IX complex concentrates, Anti-inhibitor coagulant concentrates
Increased risk of thrombosis. Avoid concomitant use.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, orthostatic hypotension, dizziness, headache, and convulsions. Management includes general supportive measures and symptomatic treatment. Maintain adequate hydration and monitor renal function.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Tranexamic acid is excreted in breast milk in small amounts; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to tranexamic acid or any component of the formulation
- Active intravascular clotting
- Severe renal impairment (risk of accumulation)
- History of convulsions
- Subarachnoid hemorrhage (risk of cerebral edema and infarction)
- Concomitant use of hormonal contraceptives (increased risk of thrombosis)
Drug Interactions
Urokinase
Reduced efficacy.
Combined hormonal contraceptives
Increased risk of thrombosis (blood clots). Avoid concomitant use.
Thrombolytic agents (e.g., Alteplase, Streptokinase)
Antagonistic effect; reduces efficacy of thrombolytics.
Factor IX complex concentrates, Anti-inhibitor coagulant concentrates
Increased risk of thrombosis. Avoid concomitant use.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, orthostatic hypotension, dizziness, headache, and convulsions. Management includes general supportive measures and symptomatic treatment. Maintain adequate hydration and monitor renal function.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Tranexamic acid is excreted in breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory bodies worldwide, including DGDA (Bangladesh)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Tranexamic acid has been extensively studied in clinical trials for various bleeding indications, including menorrhagia, trauma, and surgical bleeding, demonstrating its efficacy and safety profile.
Lab Monitoring
- Regular monitoring of renal function (creatinine, BUN) in patients with impaired kidney function.
- Periodic ophthalmologic examinations (including color vision testing) for long-term use.
- Monitor for signs and symptoms of thrombosis.
Doctor Notes
- Counsel patients on signs of thrombosis and to seek immediate medical attention if they occur.
- Assess renal function before initiating treatment and adjust dosage accordingly.
- Avoid concurrent use with hormonal contraceptives due to increased thrombotic risk.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Report any unusual bleeding or vision changes to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances in some patients. If you experience these symptoms, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hydration.
- Avoid prolonged immobility, especially if you have risk factors for blood clots.
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