Trifluxen
Generic Name
Trifluxen 15 mg tablet
Manufacturer
PharmaInnovate Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| trifluxen 15 mg tablet | ৳ 550.00 | N/A |
Description
Overview of the medicine
Trifluxen 15 mg tablet is a novel anti-inflammatory and analgesic medication used to relieve pain, reduce inflammation, and lower fever associated with various conditions.
Uses & Indications
Dosage
Adults
15 mg once daily, preferably with food.
Elderly
15 mg once daily; dose adjustment may be necessary based on renal function.
Renal_impairment
Mild to moderate impairment: 15 mg once daily. Severe impairment: Use with caution, dose reduction may be necessary or contraindicated.
Hepatic_impairment
Mild to moderate impairment: No dose adjustment needed. Severe impairment: Use with caution, consider lower dose.
How to Take
Take the tablet orally with a glass of water, preferably with food to minimize gastrointestinal discomfort. Do not crush or chew the tablet.
Mechanism of Action
Trifluxen exerts its effects by selectively inhibiting cyclooxygenase-2 (COX-2) enzymes, thereby reducing the synthesis of prostaglandins involved in pain, inflammation, and fever pathways. It has a high selectivity for COX-2, minimizing gastrointestinal side effects.
Pharmacokinetics
Onset
Analgesia: 30-60 minutes; Anti-inflammatory: several days.
Excretion
Mainly excreted through urine (60%) and feces (40%) as metabolites.
Half life
Approximately 8-10 hours.
Absorption
Rapidly and well absorbed from the gastrointestinal tract, with peak plasma concentrations reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver via CYP450 enzymes.
Side Effects
Contraindications
- Known hypersensitivity to Trifluxen or any excipients
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
Drug Interactions
Lithium
May increase lithium plasma levels.
Diuretics
May reduce diuretic efficacy and increase the risk of renal impairment.
Methotrexate
May increase methotrexate toxicity.
Other NSAIDs (including aspirin)
Increased risk of gastrointestinal adverse effects.
Warfarin and other anticoagulants
Increased risk of bleeding.
ACE inhibitors and Angiotensin II receptor blockers (ARBs)
May reduce the antihypertensive effect and increase the risk of renal impairment.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management is symptomatic and supportive. Gastric lavage or activated charcoal may be considered within the first hour of ingestion.
Pregnancy & Lactation
Pregnancy Category C (D in third trimester). Avoid use in the third trimester due to potential adverse effects on the fetal cardiovascular system. Use during pregnancy and lactation only if the potential benefit outweighs the potential risk to the fetus or infant, and consult a doctor.
Side Effects
Contraindications
- Known hypersensitivity to Trifluxen or any excipients
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
Drug Interactions
Lithium
May increase lithium plasma levels.
Diuretics
May reduce diuretic efficacy and increase the risk of renal impairment.
Methotrexate
May increase methotrexate toxicity.
Other NSAIDs (including aspirin)
Increased risk of gastrointestinal adverse effects.
Warfarin and other anticoagulants
Increased risk of bleeding.
ACE inhibitors and Angiotensin II receptor blockers (ARBs)
May reduce the antihypertensive effect and increase the risk of renal impairment.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management is symptomatic and supportive. Gastric lavage or activated charcoal may be considered within the first hour of ingestion.
Pregnancy & Lactation
Pregnancy Category C (D in third trimester). Avoid use in the third trimester due to potential adverse effects on the fetal cardiovascular system. Use during pregnancy and lactation only if the potential benefit outweighs the potential risk to the fetus or infant, and consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA and FDA
Patent Status
Patent pending (innovative drug)
Clinical Trials
Trifluxen has undergone extensive Phase I, II, and III clinical trials demonstrating its efficacy and safety profile in the treatment of various inflammatory and painful conditions. Ongoing post-marketing surveillance is collecting real-world data.
Lab Monitoring
- Complete Blood Count (CBC)
- Renal function tests (Creatinine, BUN)
- Liver function tests (ALT, AST)
- Blood pressure monitoring (especially in hypertensive patients)
Doctor Notes
- Patients should be advised to take the lowest effective dose for the shortest duration possible.
- Monitor patients for signs of gastrointestinal bleeding, cardiovascular events, and renal impairment.
- Consider co-prescription of a proton pump inhibitor for patients at high risk of GI complications.
- Assess patient response and adjust treatment plan as needed.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Report any unusual bleeding, severe stomach pain, or allergic reactions immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Trifluxen may cause dizziness or visual disturbances in some patients. If you experience these effects, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain adequate hydration.
- Adopt a balanced diet.
- Avoid alcohol consumption while on this medication.
- Discuss with your doctor about regular exercise appropriate for your condition.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.