Trigent
Generic Name
Aceclofenac
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| trigent 200 mg capsule | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Trigent 200 mg Capsule contains Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Uses & Indications
Dosage
Adults
Recommended dose is 100 mg twice daily. The 200 mg capsule may be used once daily in certain conditions or as prescribed by a physician.
Elderly
No dosage adjustment is generally required, but caution should be exercised and the lowest effective dose used.
Renal_impairment
Caution is advised. Start with a reduced dose and monitor renal function. Avoid in severe renal impairment.
How to Take
Take the capsule orally, preferably with or after food to minimize gastrointestinal discomfort. Swallow whole with water; do not chew or crush.
Mechanism of Action
Aceclofenac works by inhibiting cyclooxygenase (COX) enzymes, particularly COX-2, which are involved in the synthesis of prostaglandins. Prostaglandins are mediators of pain, inflammation, and fever. By reducing prostaglandin production, aceclofenac reduces pain and inflammation.
Pharmacokinetics
Onset
Pain relief typically begins within 30-60 minutes.
Excretion
Mainly excreted in the urine (approx. 70-80%) as metabolites and in feces (approx. 20%)
Half life
Approximately 4 hours.
Absorption
Rapidly and completely absorbed after oral administration; peak plasma concentrations reached within 1.25 to 3 hours.
Metabolism
Extensively metabolized in the liver, primarily by cytochrome P450 2C9 (CYP2C9) into 4'-hydroxyaceclofenac.
Side Effects
Contraindications
- Hypersensitivity to aceclofenac or other NSAIDs (e.g., aspirin)
- Patients with active or history of recurrent peptic ulcer/hemorrhage
- Patients with severe heart failure, hepatic failure, or renal failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Warfarin, other anticoagulants
Increased risk of bleeding.
Diuretics, ACE inhibitors, Angiotensin II receptor antagonists
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include headache, nausea, vomiting, epigastric pain, gastrointestinal bleeding, and rarely, diarrhea, disorientation, excitation, coma, drowsiness, dizziness, tinnitus, fainting, convulsions. In cases of significant poisoning, acute renal failure and liver damage are possible. Management is supportive and symptomatic; gastric lavage or activated charcoal may be considered if recent ingestion.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to risk of premature closure of the ductus arteriosus and potential fetal renal dysfunction. Use with caution during first and second trimesters only if potential benefit outweighs risk. Avoid during breastfeeding as aceclofenac may pass into breast milk.
Side Effects
Contraindications
- Hypersensitivity to aceclofenac or other NSAIDs (e.g., aspirin)
- Patients with active or history of recurrent peptic ulcer/hemorrhage
- Patients with severe heart failure, hepatic failure, or renal failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Warfarin, other anticoagulants
Increased risk of bleeding.
Diuretics, ACE inhibitors, Angiotensin II receptor antagonists
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include headache, nausea, vomiting, epigastric pain, gastrointestinal bleeding, and rarely, diarrhea, disorientation, excitation, coma, drowsiness, dizziness, tinnitus, fainting, convulsions. In cases of significant poisoning, acute renal failure and liver damage are possible. Management is supportive and symptomatic; gastric lavage or activated charcoal may be considered if recent ingestion.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to risk of premature closure of the ductus arteriosus and potential fetal renal dysfunction. Use with caution during first and second trimesters only if potential benefit outweighs risk. Avoid during breastfeeding as aceclofenac may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by drug regulatory authorities in various countries (e.g., DGDA in Bangladesh)
Patent Status
Generally off-patent
Clinical Trials
Numerous clinical trials have established the efficacy and safety of aceclofenac in various inflammatory and painful conditions, particularly musculoskeletal disorders. Ongoing research continues to explore its comparative efficacy and long-term safety profile.
Lab Monitoring
- Monitor liver function tests (ALT, AST)
- Monitor renal function (serum creatinine, BUN)
- Monitor complete blood count (CBC) during long-term therapy
- Monitor blood pressure
Doctor Notes
- Advise patients to report any signs of gastrointestinal bleeding or cardiovascular symptoms immediately.
- Regular monitoring of renal and hepatic function is crucial for long-term users.
- Consider proton pump inhibitors for patients at high risk of GI complications.
Patient Guidelines
- Take with food to minimize stomach upset.
- Do not exceed the recommended dose.
- Inform your doctor about any pre-existing medical conditions, especially heart, kidney, or liver problems.
- Avoid alcohol consumption while taking this medicine.
- Seek immediate medical attention if you experience severe abdominal pain, black stools, or unusual bleeding.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or visual disturbances. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet and regular exercise as advised by your doctor.
- Avoid smoking and excessive alcohol consumption.
- Regular follow-ups with your doctor are recommended, especially for long-term use.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.