Trimotil
Generic Name
Trimetazidine 100 mg tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| trimotil 100 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Trimetazidine is a cytoprotective anti-ischemic agent used for the symptomatic treatment of angina pectoris, vertigo, and tinnitus. It works by optimizing myocardial energy metabolism.
Uses & Indications
Dosage
Adults
100 mg once daily (extended-release tablet), preferably with meals.
Elderly
No specific dose adjustment is required unless there is moderate to severe renal impairment. Careful titration is recommended.
Renal_impairment
In patients with moderate renal impairment (creatinine clearance 30-60 mL/min), the dose should be reduced. Consult physician for dose adjustment. Not recommended for severe renal impairment (creatinine clearance < 30 mL/min).
How to Take
For oral use. Tablets should be swallowed whole with a glass of water, preferably with meals. Do not chew or crush the tablet.
Mechanism of Action
Trimetazidine inhibits the 3-ketoacyl-CoA thiolase (3-KAT) enzyme, thereby shifting cardiac energy metabolism from fatty acid oxidation to glucose oxidation. This improves glucose utilization, reduces oxygen consumption, and maintains ATP levels in ischemic cells, thus protecting against ischemia.
Pharmacokinetics
Onset
Clinical effects may be observed within a few days to a week of regular administration.
Excretion
Mainly excreted unchanged in the urine.
Half life
Approximately 6 hours for immediate release, extended to 7-12 hours for modified/extended release formulations.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentration reached within 2 hours for immediate release, with extended release showing sustained levels.
Metabolism
Minimally metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to Trimetazidine or any excipients
- Parkinson's disease, parkinsonian symptoms, tremors, restless leg syndrome, and other related movement disorders
- Severe renal impairment (creatinine clearance < 30 mL/min)
Drug Interactions
General
Trimetazidine has a low potential for drug interactions. No clinically significant interactions have been reported with commonly used drugs.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. In case of an overdose, symptomatic treatment and supportive measures should be initiated. Contact your doctor or emergency services.
Pregnancy & Lactation
Not recommended during pregnancy due to insufficient data. Breastfeeding should be avoided as it is unknown if Trimetazidine is excreted in human milk. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Trimetazidine or any excipients
- Parkinson's disease, parkinsonian symptoms, tremors, restless leg syndrome, and other related movement disorders
- Severe renal impairment (creatinine clearance < 30 mL/min)
Drug Interactions
General
Trimetazidine has a low potential for drug interactions. No clinically significant interactions have been reported with commonly used drugs.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. In case of an overdose, symptomatic treatment and supportive measures should be initiated. Contact your doctor or emergency services.
Pregnancy & Lactation
Not recommended during pregnancy due to insufficient data. Breastfeeding should be avoided as it is unknown if Trimetazidine is excreted in human milk. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved in many countries including Bangladesh
Patent Status
Generic
Clinical Trials
Numerous clinical trials have demonstrated Trimetazidine's efficacy and safety in the symptomatic treatment of stable angina pectoris and other indications, particularly in improving exercise tolerance and reducing angina attacks.
Lab Monitoring
- No routine lab monitoring is typically required, but renal function should be assessed in elderly patients or those with pre-existing renal impairment.
Doctor Notes
- Advise patients to report any new or worsening movement disorders immediately.
- Exercise caution in elderly patients and those with moderate renal impairment, considering dose reduction.
- Not indicated for the treatment of an angina attack, but as a chronic therapy.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Do not stop taking Trimetazidine suddenly without consulting your doctor.
- Report any new or worsening movement disorders to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for the missed one.
Driving Precautions
Trimetazidine may cause dizziness and drowsiness. Patients should be cautioned against driving or operating machinery if these symptoms occur.
Lifestyle Advice
- Maintain a heart-healthy diet and engage in regular physical activity.
- Avoid smoking and limit alcohol consumption to support cardiovascular health.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.