Trin
Generic Name
Trin-5-mg-syrup
Manufacturer
Example Pharmaceutical Co. (Generic)
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| trin 5 mg syrup | ৳ 28.75 | N/A |
Description
Overview of the medicine
Trin-5-mg-syrup is a first-generation antihistamine, commonly containing Triprolidine Hydrochloride, used to relieve symptoms of allergic reactions such as sneezing, runny nose, watery eyes, and itching. It also has mild sedative effects.
Uses & Indications
Dosage
Adults
5 mg (5 mL) every 4-6 hours; maximum 20 mg (20 mL) in 24 hours.
Elderly
Lower initial dose may be considered; caution due to increased susceptibility to side effects.
Renal_impairment
No specific dose adjustment provided, but caution advised due to renal excretion of metabolites.
How to Take
For oral administration. Measure the dose accurately using a measuring spoon or cup. Can be taken with or without food.
Mechanism of Action
The active component (e.g., Triprolidine Hydrochloride) works by blocking the action of histamine at H1-receptors, thereby reducing histamine-mediated allergic symptoms. It also possesses anticholinergic properties.
Pharmacokinetics
Onset
Within 15-30 minutes.
Excretion
Mainly excreted in the urine as metabolites.
Half life
Approximately 3 to 6 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract after oral administration.
Metabolism
Extensively metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Triprolidine or any component of the syrup
- Patients with severe respiratory depression or acute asthmatic attack
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of stopping MAOI therapy
- Newborns or premature infants
Drug Interactions
Monoamine Oxidase Inhibitors (MAOIs)
Contraindicated due to risk of hypertensive crisis and severe adverse effects.
CNS Depressants (e.g., alcohol, sedatives, hypnotics)
Increased central nervous system depression, leading to enhanced drowsiness and sedation.
Anticholinergic drugs (e.g., tricyclic antidepressants, atropine)
Potentiation of anticholinergic side effects such as dry mouth, blurred vision, and urinary retention.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe drowsiness, dizziness, incoordination, dry mouth, fixed dilated pupils, flushing, gastrointestinal upset, and in severe cases, convulsions or coma. Management involves symptomatic and supportive treatment, including gastric lavage or activated charcoal if recent ingestion, and maintaining vital signs.
Pregnancy & Lactation
Pregnancy Category B/C. Use during pregnancy only if clearly needed and the benefits outweigh the potential risks. Not recommended during breastfeeding as it can pass into breast milk and cause drowsiness in the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Globally available in pharmacies
Approval Status
Approved in various countries globally
Patent Status
Off-patent
Clinical Trials
Early clinical trials established the efficacy and safety of Triprolidine as a first-generation antihistamine for allergic conditions and common cold symptoms. Ongoing surveillance monitors post-market safety.
Lab Monitoring
- Generally no routine lab monitoring is required. Liver and kidney function tests may be considered in patients with pre-existing impairment or long-term use.
Doctor Notes
- Advise patients regarding potential for significant drowsiness and to avoid activities requiring alertness, especially at the start of therapy.
- Counsel on avoiding alcohol and other CNS depressants due to additive effects.
- Caution in elderly and patients with prostatic hypertrophy, narrow-angle glaucoma, or severe hepatic/renal impairment due to anticholinergic effects and metabolism/excretion pathways.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid driving or operating heavy machinery due to drowsiness.
- Avoid alcohol consumption while taking this medicine.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
Trin-5-mg-syrup may cause drowsiness, dizziness, or blurred vision. Patients should be warned not to drive, operate machinery, or perform tasks requiring mental alertness until they know how the drug affects them.
Lifestyle Advice
- Ensure adequate hydration, especially when suffering from cold symptoms. Rest sufficiently to aid recovery.
- Avoid exposure to known allergens to minimize symptoms.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.