Trioson
Generic Name
Budesonide, Formoterol Fumarate, and Glycopyrronium Inhaler
Manufacturer
Hypothetical Pharma Co.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| trioson 100 mcg inhaler | ৳ 750.00 | N/A |
Description
Overview of the medicine
Trioson-100-mcg-inhaler is a triple combination therapy used for the maintenance treatment of chronic obstructive pulmonary disease (COPD) and asthma. It contains an inhaled corticosteroid (budesonide), a long-acting beta2-agonist (formoterol fumarate), and a long-acting muscarinic antagonist (glycopyrronium) to improve lung function and reduce exacerbations.
Uses & Indications
Dosage
Adults
Two inhalations twice daily (morning and evening).
Elderly
No specific dose adjustment required based on age.
Renal_impairment
No specific dose adjustment required, but use with caution in severe impairment.
How to Take
For oral inhalation only. Shake the inhaler well before each use. Inhale slowly and deeply through the mouth, pressing down on the canister, then hold breath for 5-10 seconds. Rinse mouth after each use to prevent oral candidiasis.
Mechanism of Action
Budesonide is an anti-inflammatory corticosteroid. Formoterol fumarate is a selective long-acting beta2-adrenergic agonist that relaxes bronchial smooth muscle. Glycopyrronium is a long-acting muscarinic antagonist that inhibits bronchoconstriction. Together, they provide bronchodilation and reduce airway inflammation.
Pharmacokinetics
Onset
Bronchodilation within 5-15 minutes (Formoterol, Glycopyrronium).
Excretion
Primarily via urine and feces for all components, with budesonide mainly as metabolites.
Half life
Budesonide ~2-4 hours; Formoterol ~10 hours; Glycopyrronium ~15 hours.
Absorption
Budesonide is absorbed systemically, with peak plasma concentration at 30 min. Formoterol is rapidly absorbed. Glycopyrronium has low systemic absorption after inhalation.
Metabolism
Budesonide undergoes extensive first-pass metabolism in the liver. Formoterol is metabolized by direct glucuronidation and O-demethylation. Glycopyrronium is minimally metabolized.
Side Effects
Contraindications
- Hypersensitivity to any active substance or excipient
- Acute bronchospasm or status asthmaticus
Drug Interactions
Anticholinergics
May have additive systemic effects with glycopyrronium.
Strong CYP3A4 inhibitors
May increase systemic exposure to budesonide (e.g., ketoconazole, ritonavir).
Beta-blockers (non-cardioselective)
May antagonize the bronchodilating effect of formoterol.
Storage
Store at controlled room temperature (20-25°C). Do not puncture or incinerate. Keep away from heat and direct sunlight. Keep out of reach of children.
Overdose
Symptoms of overdose include tremor, palpitations, tachycardia, headache (formoterol); systemic corticosteroid effects (budesonide); blurred vision, dry mouth, urinary retention (glycopyrronium). Treatment is supportive and symptomatic.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to any active substance or excipient
- Acute bronchospasm or status asthmaticus
Drug Interactions
Anticholinergics
May have additive systemic effects with glycopyrronium.
Strong CYP3A4 inhibitors
May increase systemic exposure to budesonide (e.g., ketoconazole, ritonavir).
Beta-blockers (non-cardioselective)
May antagonize the bronchodilating effect of formoterol.
Storage
Store at controlled room temperature (20-25°C). Do not puncture or incinerate. Keep away from heat and direct sunlight. Keep out of reach of children.
Overdose
Symptoms of overdose include tremor, palpitations, tachycardia, headache (formoterol); systemic corticosteroid effects (budesonide); blurred vision, dry mouth, urinary retention (glycopyrronium). Treatment is supportive and symptomatic.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 months from manufacturing date, check package for specific expiry.
Availability
Pharmacies and hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Varies by specific formulation and region; generics might be available
Clinical Trials
Extensive clinical trials (e.g., KRONOS, ETHOS for Breztri; TRIMARAN, TRIBUTE for Trimbow) have demonstrated efficacy and safety in COPD and asthma patients.
Lab Monitoring
- Regular monitoring of lung function (FEV1)
- Bone mineral density (long-term ICS use)
- Ocular exams for cataracts/glaucoma (long-term ICS use)
- Serum potassium levels (with LABA)
Doctor Notes
- Emphasize proper inhaler technique to patients, including rinsing mouth after use.
- Advise patients that this is a maintenance therapy, not for acute symptom relief.
- Regularly assess for exacerbations and adjust therapy as needed.
- Monitor for potential side effects, particularly oral candidiasis and systemic effects with long-term use.
Patient Guidelines
- Use regularly as prescribed, even if you feel well.
- Rinse your mouth with water and spit after each use to prevent oral thrush.
- Do not use for sudden breathing problems; use a rapid-acting bronchodilator for rescue.
- Report any worsening of symptoms or side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
Generally, does not affect ability to drive. However, if experiencing dizziness or blurred vision, avoid driving or operating machinery until effects subside.
Lifestyle Advice
- Avoid smoking and exposure to respiratory irritants.
- Maintain good hydration.
- Practice breathing exercises as advised by your healthcare provider.
- Ensure regular follow-ups with your doctor.
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