Triquin
Generic Name
Triamcinolone Acetonide + Clotrimazole + Gentamicin Sulfate
Manufacturer
ABC Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| triquin 001 4 cream | ৳ 200.00 | N/A |
Description
Overview of the medicine
Triquin-001-4-Cream is a combination topical preparation containing a corticosteroid (Triamcinolone Acetonide), an antifungal (Clotrimazole), and an antibiotic (Gentamicin Sulfate). It is used to treat various inflammatory and infective dermatoses where bacterial and/or fungal infections are present or suspected.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected skin area 2-3 times daily. Gently rub in. Treatment should not exceed 2 weeks without medical review.
Elderly
No specific dosage adjustment required. Use with caution on thin skin areas and for prolonged periods.
Renal_impairment
No dosage adjustment required for topical application due to minimal systemic absorption.
How to Take
For external use only. Cleanse the affected area before application. Apply a small amount of cream to cover the affected skin, then gently rub it in. Wash hands thoroughly after application.
Mechanism of Action
Triamcinolone Acetonide is a corticosteroid that reduces inflammation, itching, and redness. Clotrimazole is an antifungal agent that works by inhibiting ergosterol synthesis, a vital component of fungal cell membranes, leading to fungal cell death. Gentamicin Sulfate is an aminoglycoside antibiotic that inhibits bacterial protein synthesis, thereby killing susceptible bacteria.
Pharmacokinetics
Onset
Local anti-inflammatory and antimicrobial effects observed within days of initiation.
Excretion
Systemically absorbed components are primarily excreted via urine and bile.
Half life
Not well characterized for topical application; local duration of action depends on formulation and application.
Absorption
Minimal systemic absorption through intact skin. Absorption may increase with inflammation, occlusive dressings, or application to large surface areas.
Metabolism
Absorbed corticosteroids are primarily metabolized in the liver. Clotrimazole and Gentamicin undergo minimal systemic metabolism with topical use.
Side Effects
Contraindications
- Hypersensitivity to Triamcinolone Acetonide, Clotrimazole, Gentamicin Sulfate, or any excipients.
- Viral skin infections (e.g., herpes simplex, varicella).
- Tuberculosis of the skin.
- Acne vulgaris, rosacea, perioral dermatitis.
- Children under 2 years of age (due to corticosteroid component).
Drug Interactions
Other topical corticosteroids
Concurrent use may increase the risk of systemic absorption and local side effects.
Topical antifungals/antibiotics
Generally compatible, but avoid excessive overlapping products.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Systemic overdose is unlikely with appropriate topical use. Excessive or prolonged application, especially on large areas or under occlusive dressings, may lead to local adverse effects or, rarely, signs of hypercorticism (e.g., Cushing's syndrome) due to systemic absorption of the corticosteroid.
Pregnancy & Lactation
Consult a physician before use during pregnancy or lactation. Use with caution, especially on large surface areas or for prolonged periods, as systemic absorption may occur. Risk-benefit should be assessed.
Side Effects
Contraindications
- Hypersensitivity to Triamcinolone Acetonide, Clotrimazole, Gentamicin Sulfate, or any excipients.
- Viral skin infections (e.g., herpes simplex, varicella).
- Tuberculosis of the skin.
- Acne vulgaris, rosacea, perioral dermatitis.
- Children under 2 years of age (due to corticosteroid component).
Drug Interactions
Other topical corticosteroids
Concurrent use may increase the risk of systemic absorption and local side effects.
Topical antifungals/antibiotics
Generally compatible, but avoid excessive overlapping products.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Systemic overdose is unlikely with appropriate topical use. Excessive or prolonged application, especially on large areas or under occlusive dressings, may lead to local adverse effects or, rarely, signs of hypercorticism (e.g., Cushing's syndrome) due to systemic absorption of the corticosteroid.
Pregnancy & Lactation
Consult a physician before use during pregnancy or lactation. Use with caution, especially on large surface areas or for prolonged periods, as systemic absorption may occur. Risk-benefit should be assessed.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
Clinical Trials
Clinical trials have demonstrated the efficacy and safety of this combination cream in treating various inflammatory and infective dermatoses.
Lab Monitoring
- Not routinely required for typical topical use.
- For prolonged use on large areas, periodic monitoring for hypothalamic-pituitary-adrenal (HPA) axis suppression may be considered.
Doctor Notes
- Emphasize proper application technique and duration to patients.
- Advise against using on facial skin or in intertriginous areas for extended periods.
- Educate on signs of fungal or bacterial superinfection.
- Consider alternative treatments if no improvement after 1-2 weeks.
Patient Guidelines
- Use only as directed by your doctor.
- Do not use for longer than prescribed, especially on the face, groin, or in children.
- Avoid contact with eyes, mouth, and mucous membranes.
- Do not cover the treated area with bandages or other occlusive dressings unless advised by your doctor.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one.
Driving Precautions
Triquin-001-4-Cream is for topical use and is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good skin hygiene to prevent recurrence of infections.
- Avoid sharing towels or personal items.
- Wear loose, breathable clothing.
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Global Brand Names
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