Trisela
Generic Name
Iron Sucrose Injection
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| trisela 300 mg injection | ৳ 15,000.00 | N/A |
Description
Overview of the medicine
Trisela 300 mg Injection contains Iron Sucrose, a complex of polynuclear iron(III)-hydroxide and sucrose. It is used for the treatment of iron deficiency anemia in various patient populations, particularly when oral iron preparations are ineffective or contraindicated.
Uses & Indications
Dosage
Adults
The total cumulative dose is determined by the patient's baseline hemoglobin, body weight, and iron deficit. Typically, 100-300 mg of iron is administered intravenously once to thrice weekly.
Elderly
No specific dose adjustments are typically required for elderly patients, but caution is advised due to potential comorbidities.
Renal_impairment
Dosage is similar to adults; closely monitor iron parameters.
How to Take
Trisela 300 mg Injection should only be administered by slow intravenous injection or intravenous drip infusion by appropriately trained healthcare professionals. It should not be administered intramuscularly.
Mechanism of Action
Iron sucrose replenishes iron stores in the body, which is then incorporated into hemoglobin, myoglobin, and iron-containing enzymes. The iron(III) in the complex is released slowly and binds to transferrin for transport to hematopoietic cells and stored as ferritin.
Pharmacokinetics
Onset
Hemoglobin increase is typically observed within 2-4 weeks.
Excretion
Mainly through the reticuloendothelial system. Small amounts of intact iron sucrose may be excreted renally.
Half life
The iron component has a half-life of 6 hours in circulation; the sucrose component is rapidly eliminated.
Absorption
Following intravenous administration, the sucrose component is largely cleared, and iron is released into the reticuloendothelial system.
Metabolism
Iron is not metabolized in the liver but incorporated into ferritin and hemoglobin. Sucrose is metabolized or excreted.
Side Effects
Contraindications
- Known hypersensitivity to iron sucrose or any of its components.
- Anemia not caused by iron deficiency (e.g., hemolytic anemia).
- Evidence of iron overload or disturbances in iron utilization.
- First trimester of pregnancy (relative contraindication).
Drug Interactions
ACE inhibitors
Potentiates hypotensive effects, especially in patients on dialysis.
Oral iron preparations
Concomitant use with oral iron preparations may reduce the absorption of oral iron. Oral iron should be started only after at least 5 days following the last injection.
Storage
Store at room temperature (20°C to 25°C), protect from light. Do not freeze.
Overdose
Overdose can lead to iron overload, which may manifest as hemochromatosis. Treatment involves symptomatic and supportive measures, including iron chelating agents like deferoxamine.
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy only if clearly needed after assessing risks and benefits. Small amounts of iron may pass into breast milk, but adverse effects on the infant are unlikely. Consult a doctor.
Side Effects
Contraindications
- Known hypersensitivity to iron sucrose or any of its components.
- Anemia not caused by iron deficiency (e.g., hemolytic anemia).
- Evidence of iron overload or disturbances in iron utilization.
- First trimester of pregnancy (relative contraindication).
Drug Interactions
ACE inhibitors
Potentiates hypotensive effects, especially in patients on dialysis.
Oral iron preparations
Concomitant use with oral iron preparations may reduce the absorption of oral iron. Oral iron should be started only after at least 5 days following the last injection.
Storage
Store at room temperature (20°C to 25°C), protect from light. Do not freeze.
Overdose
Overdose can lead to iron overload, which may manifest as hemochromatosis. Treatment involves symptomatic and supportive measures, including iron chelating agents like deferoxamine.
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy only if clearly needed after assessing risks and benefits. Small amounts of iron may pass into breast milk, but adverse effects on the infant are unlikely. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date, check specific packaging.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of iron sucrose in various populations with iron deficiency anemia. Ongoing research continues to optimize dosing regimens and explore new indications.
Lab Monitoring
- Hemoglobin (Hb)
- Serum ferritin
- Transferrin saturation (TSAT)
- Complete blood count (CBC)
Doctor Notes
- Assess iron status (ferritin, TSAT, Hb) before and during treatment.
- Administer a test dose to patients at high risk of hypersensitivity.
- Monitor for signs of anaphylaxis during and immediately after administration. Ensure resuscitation equipment is available.
Patient Guidelines
- Report any unusual symptoms or allergic reactions immediately to your healthcare provider during or after administration.
- Do not try to administer this medication yourself; it must be given by a healthcare professional.
- Ensure you understand the full course of treatment and follow up as advised by your doctor.
Missed Dose Advice
If a dose is missed, contact your doctor or healthcare provider to reschedule the next dose. Do not double the dose to compensate for a missed one.
Driving Precautions
This medicine may cause dizziness or lightheadedness. Avoid driving or operating machinery until you know how it affects you.
Lifestyle Advice
- Maintain a balanced diet rich in iron, if possible, in conjunction with treatment.
- Stay hydrated during treatment.
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