Trispray
Generic Name
Triamcinolone Acetonide
Manufacturer
Generic Pharma Co.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| trispray 55 mcg nasal spray | ৳ 201.00 | N/A |
Description
Overview of the medicine
Trispray 55 mcg Nasal Spray contains Triamcinolone Acetonide, a corticosteroid used to treat symptoms of seasonal and perennial allergic rhinitis, including sneezing, runny nose, nasal itching, and congestion. It works by reducing inflammation in the nasal passages.
Uses & Indications
Dosage
Adults
Initially, 2 sprays in each nostril once daily. Once symptoms are controlled, dose may be reduced to 1 spray in each nostril once daily. Maximum dose is 2 sprays in each nostril once daily.
Elderly
No dosage adjustment is generally required for elderly patients.
Children_over_2
Children 2 to 12 years of age: Initially, 1 spray in each nostril once daily. If symptoms persist, dosage may be increased to 2 sprays in each nostril once daily. Once symptoms are controlled, dose may be reduced to 1 spray in each nostril once daily. Do not exceed recommended dosage.
Renal_impairment
No dosage adjustment is necessary.
Hepatic_impairment
No dosage adjustment is necessary.
How to Take
For nasal administration only. Shake the bottle gently before use. Prime the pump before first use or if not used for more than 2 weeks. Insert the nozzle into one nostril, closing the other, and spray while breathing in gently. Repeat for the other nostril. Avoid spraying into the eyes or mouth.
Mechanism of Action
Triamcinolone Acetonide is a potent glucocorticoid with anti-inflammatory properties. It works by binding to glucocorticoid receptors in the nasal mucosa, thereby inhibiting the release of inflammatory mediators (e.g., histamine, prostaglandins, leukotrienes) and reducing the migration of inflammatory cells (e.g., eosinophils, mast cells). This leads to a reduction in swelling, itching, and mucus production in the nasal passages.
Pharmacokinetics
Onset
Onset of symptom relief can occur within 3-4 hours, with maximal effect seen after 3-4 days of continuous use.
Excretion
Excreted mainly via urine and feces as metabolites.
Half life
The plasma half-life of triamcinolone acetonide is approximately 2-3 hours.
Absorption
Systemic absorption of triamcinolone acetonide from nasal administration is low, typically less than 1-2%. Peak plasma concentrations occur 1-2 hours after administration.
Metabolism
Primarily metabolized in the liver by CYP3A4 enzymes.
Side Effects
Contraindications
- •Hypersensitivity to triamcinolone acetonide or any component of the formulation.
- •Untreated localized infection involving the nasal mucosa.
Drug Interactions
Ketoconazole (and other CYP3A4 inhibitors)
Concurrent use may increase systemic exposure to triamcinolone, requiring caution.
Ritonavir (and other strong CYP3A4 inhibitors)
Potential for increased systemic corticosteroid effects; monitor for adverse reactions.
Storage
Store below 30°C. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose with Trispray is unlikely due to its low systemic absorption. Chronic overdose may lead to signs and symptoms of hypercorticism, including Cushing's syndrome. Management involves discontinuation of the drug and symptomatic supportive therapy.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known if triamcinolone acetonide is excreted in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture. Once opened, use within 2 months.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Generics available, original patent expired
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Global Brand Names
International brand names for this medicine
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