Tritin
Generic Name
Tritinamide
Manufacturer
MediCare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tritin 100 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Tritin 100 mg Tablet contains Tritinamide, a novel agent used for the management of neuropathic pain, including painful diabetic neuropathy and post-herpetic neuralgia. It works by modulating specific calcium channels in the central nervous system.
Uses & Indications
Dosage
Adults
Initial dose is 100 mg once daily, adjusted based on response and tolerability up to 300 mg daily in divided doses. Max 600 mg/day.
Elderly
Start with 50 mg once daily, gradually increase with caution due to potential for increased sensitivity and renal impairment.
Renal_impairment
For CrCl 30-60 mL/min, reduce dose by 50%. For CrCl <30 mL/min, reduce dose by 75% or administer every other day.
How to Take
Tritin 100 mg Tablet should be swallowed whole with water, with or without food. Do not crush, chew, or break the tablet.
Mechanism of Action
Tritinamide selectively binds to the alpha-2-delta subunit of voltage-gated calcium channels in the presynaptic terminals of neurons, particularly in the dorsal horn of the spinal cord. This binding reduces the influx of calcium ions, thereby decreasing the release of excitatory neurotransmitters such as glutamate, substance P, and norepinephrine. This action ultimately attenuates the hyperexcitability of neurons associated with neuropathic pain.
Pharmacokinetics
Onset
Pain relief typically begins within 1-2 weeks of consistent dosing, with full effect seen after 4 weeks.
Excretion
Primarily excreted unchanged in the urine; approximately 98% of the administered dose is recovered in urine.
Half life
6-7 hours, not significantly altered in patients with mild to moderate renal impairment.
Absorption
Rapidly absorbed after oral administration, bioavailability is approximately 90% and is not affected by food. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Minimal hepatic metabolism; less than 5% is metabolized. Primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to Tritinamide or any excipients
- Acute porphyria
Drug Interactions
Antacids
Antacids containing aluminum and magnesium may reduce the bioavailability of Tritinamide. Administer Tritinamide at least 2 hours after antacids.
CNS Depressants
Concomitant use with other CNS depressants (e.g., opioids, benzodiazepines, alcohol) may enhance CNS depression and increase risk of dizziness and somnolence.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe dizziness, somnolence, blurred vision, slurred speech, and lethargy. Treatment is primarily supportive; gastric lavage or activated charcoal may be considered in recent ingestions. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether Tritinamide is excreted in human milk; caution is advised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to Tritinamide or any excipients
- Acute porphyria
Drug Interactions
Antacids
Antacids containing aluminum and magnesium may reduce the bioavailability of Tritinamide. Administer Tritinamide at least 2 hours after antacids.
CNS Depressants
Concomitant use with other CNS depressants (e.g., opioids, benzodiazepines, alcohol) may enhance CNS depression and increase risk of dizziness and somnolence.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe dizziness, somnolence, blurred vision, slurred speech, and lethargy. Treatment is primarily supportive; gastric lavage or activated charcoal may be considered in recent ingestions. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether Tritinamide is excreted in human milk; caution is advised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Patent Pending (Bangladesh)
Clinical Trials
Phase III clinical trials demonstrated significant reduction in neuropathic pain scores compared to placebo, with good tolerability profile.
Lab Monitoring
- Monitor renal function (CrCl) periodically, especially in elderly patients and those with pre-existing renal impairment.
- Liver function tests (LFTs) if clinical symptoms suggest hepatic dysfunction.
Doctor Notes
- Counsel patients about potential dizziness and somnolence, especially at initiation.
- Emphasize gradual tapering to avoid withdrawal symptoms.
- Monitor renal function, particularly in elderly and renally impaired patients.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking Tritin suddenly, as it may lead to withdrawal symptoms. Gradual tapering is recommended.
- Avoid driving or operating heavy machinery until you know how Tritin affects you, as it may cause dizziness or somnolence.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause dizziness, somnolence, or blurred vision. Patients should be cautioned against operating hazardous machinery or driving until they are reasonably certain that Tritinamide therapy does not adversely affect their ability to engage in such activities.
Lifestyle Advice
- Maintain a healthy diet and regular exercise routine to manage overall health.
- Avoid alcohol while on Tritinamide due to enhanced CNS depressant effects.
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