Tromark
Generic Name
Atorvastatin Calcium
Manufacturer
Square Pharmaceuticals Plc.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tromark 10 mg tablet | ৳ 8.00 | N/A |
Description
Overview of the medicine
Tromark 10 mg Tablet contains Atorvastatin, a statin, used to lower high cholesterol and triglyceride levels in the blood. It helps reduce the risk of heart attack, stroke, and other cardiovascular problems.
Uses & Indications
Dosage
Adults
Initial dose 10-20 mg once daily. Max dose 80 mg once daily. Adjust dosage based on LDL-C levels and patient response. For Tromark 10 mg: 1 tablet daily, preferably at the same time each day.
Elderly
No dosage adjustment required based on age alone. Follow adult dosage.
Renal_impairment
No dosage adjustment required for renal impairment.
How to Take
Tromark 10 mg Tablet can be taken orally, with or without food, at any time of the day. It is recommended to take it at the same time each day to maintain consistent drug levels.
Mechanism of Action
Atorvastatin selectively inhibits HMG-CoA reductase, an enzyme that catalyzes the early rate-limiting step in cholesterol biosynthesis. This inhibition reduces cholesterol production in the liver and increases the number of LDL receptors on liver cells, leading to increased clearance of LDL cholesterol from the blood.
Pharmacokinetics
Onset
Lipid-lowering effects are evident within 2 weeks, with maximum effect typically seen within 4 weeks.
Excretion
Primarily excreted in the bile following hepatic and/or extrahepatic metabolism. Less than 2% of the dose is recovered in the urine.
Half life
Approximately 14 hours for the parent drug; the active metabolites contribute to an extended plasma half-life of 20-30 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations usually occur within 1-2 hours. Absolute bioavailability is approximately 12%.
Metabolism
Extensively metabolized by cytochrome P450 3A4 (CYP3A4) to active ortho- and parahydroxylated metabolites and inactive beta-oxidation products.
Side Effects
Contraindications
- Hypersensitivity to Atorvastatin or any component of the tablet
- Active liver disease or unexplained persistent elevations of serum transaminases
- Pregnancy and lactation (or women of childbearing potential not using adequate contraception)
Drug Interactions
Warfarin
Potentiation of anticoagulant effect.
Erythromycin, Clarithromycin, Azithromycin, Itraconazole, Ketoconazole
Increased plasma concentrations of atorvastatin.
Cyclosporine, Gemfibrozil, Niacin, Protease inhibitors (e.g., Ritonavir)
Increased risk of myopathy/rhabdomyolysis.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. In case of overdose, supportive measures should be taken as clinically indicated. Hemodialysis is not expected to significantly enhance atorvastatin clearance.
Pregnancy & Lactation
Atorvastatin is contraindicated during pregnancy and breastfeeding. It can cause fetal harm. Women of childbearing potential should use adequate contraception.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in pharmacies, hospitals, and clinics
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available (original patent expired)
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous clinical trials such as the ASCOT-LLA, MIRACL, TNT, and CARDS trials, demonstrating significant reductions in cardiovascular events and mortality.
Lab Monitoring
- Liver function tests (ALT/AST) before starting treatment and periodically thereafter
- Lipid panel (Total cholesterol, LDL-C, HDL-C, Triglycerides) periodically to assess efficacy
- Creatine Kinase (CK) if muscle symptoms occur
Doctor Notes
- Advise patients on lifestyle modifications (diet, exercise).
- Monitor liver function tests and lipid profiles regularly.
- Educate patients on signs of myopathy and advise immediate reporting.
Patient Guidelines
- Take this medicine regularly as prescribed by your doctor, even if you feel well.
- Continue a cholesterol-lowering diet and exercise program while taking this medicine.
- Report any unexplained muscle pain, tenderness, or weakness to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Tromark is generally not expected to affect the ability to drive or operate machinery. However, if you experience dizziness or other side effects that could impair concentration, avoid driving.
Lifestyle Advice
- Adopt a low-fat, low-cholesterol diet.
- Regular physical activity is encouraged.
- Maintain a healthy weight.
- Limit alcohol consumption and avoid smoking.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.